Actively Recruiting
Panomic Approach to Immune-Connected Assays in Small Cell Lung Cancer
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2023-04-04
100
Participants Needed
1
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The scope of the PICASSO project is to apply an innovative patient-based pan-omic approach to immune-assays, that will include multi-omics tumour characterization (genome, proteome, transcriptome), blood immune-cells and cytokine profiling, serological screening for paraneoplastic autoantibodies, clinical and metabolic measurements. The PICASSO project is aimed to validate in real world population the predictive role of SCLC transcriptomic classification (particularly, I-SCLC subtype) and to explore correlations with dynamic changes in peripheral blood immunity. Additionally, investigators expected to validate the predictive/prognostic role of emerging new variables, including metabolic-induced meta-inflammation alterations and subclinical auto-immunity.
CONDITIONS
Official Title
Panomic Approach to Immune-Connected Assays in Small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically- or cytologically-confirmed extensive-stage small cell lung cancer
- Received upfront treatment with Cisplatin or Carboplatin, etoposide, and anti PD1/PD-L1 inhibitors
- No evidence of brain metastases at diagnosis
- ECOG performance status of 0 to 2
- Adults aged 18 years or older at diagnosis
- Signed informed consent approved by the local Ethics Committee
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fondazione Policlinico Gemelli IRCCS
Rome, Italy, 00168
Actively Recruiting
Research Team
E
Emilio Bria, Prof.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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