Actively Recruiting
Parasitic Ulcer Treatment Trial
Led by Jeremy Keenan, MD, MPH · Updated on 2026-05-01
232
Participants Needed
17
Research Sites
260 weeks
Total Duration
On this page
Sponsors
J
Jeremy Keenan, MD, MPH
Lead Sponsor
J
Johns Hopkins University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis (AK) will improve vision. Patients presenting to all enrollment centers with evidence of acanthamoeba keratitis will be eligible for the trial if there is evidence of ocular inflammation after 4 weeks of anti-amoebic therapy. Those who agree to participate will be randomized to one of two treatment groups: * Group 1: Topical corticosteroid * Group 2: Topical placebo
CONDITIONS
Official Title
Parasitic Ulcer Treatment Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acanthamoeba keratitis confirmed by culture, smear, PCR, shotgun sequencing, biopsy, or confocal microscopy
- Evidence of ocular inflammation after at least 1 month of anti-amoebic treatment, including inflammation of the conjunctiva, cornea, episclera, or anterior chamber
- Age 8 years or older
You will not qualify if you...
- History or evidence of interstitial keratitis
- Known herpetic keratitis based on history, exam, or microbiological testing
- Known fungal keratitis confirmed by corneal scrapings
- Corneal perforation or risk of imminent corneal perforation
- Previous therapeutic keratoplasty for acanthamoeba keratitis
- Unwillingness or inability to participate in follow-up visits
- No light perception in the affected eye
- Known hypertensive response to steroids
- Allergy to corticosteroids
- Current treatment with systemic corticosteroids
- Concurrent granulomatous amoebic encephalitis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
University of California, San Francisco
San Francisco, California, United States, 94158
Actively Recruiting
2
University of Colorado Anschutz
Aurora, Colorado, United States, 80045
Actively Recruiting
3
University of Florida
Gainesville, Florida, United States, 32605
Actively Recruiting
4
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
5
University of Illinois, Chicago
Chicago, Illinois, United States, 60612
Actively Recruiting
6
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
7
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
8
Columbia University
New York, New York, United States, 10032
Actively Recruiting
9
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
10
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
11
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15219
Actively Recruiting
12
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
13
University of Washington
Seattle, Washington, United States, 98104
Actively Recruiting
14
Federal University of São Paulo
São Paulo, Brazil
Actively Recruiting
15
Aravind Eye Hospital
Coimbatore, Tamil Nadu, India
Actively Recruiting
16
Aravind Eye Hospital
Madurai, Tamil Nadu, India
Actively Recruiting
17
Moorfields Eye Hospital
London, United Kingdom
Actively Recruiting
Research Team
J
Jeremy Keenan, MD, MPH
CONTACT
K
Krisi Aromin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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