Actively Recruiting
Parathyroid Allotransplant for Severe Refractory Hypoparathyroidism
Led by Karen Devon · Updated on 2024-07-12
5
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
K
Karen Devon
Lead Sponsor
U
University Health Network, Toronto
Collaborating Sponsor
AI-Summary
What this Trial Is About
Hypoparathyroidism following thyroid surgery presents significant challenges, often leading to debilitating symptoms and reduced quality of life despite conventional treatment. Having now reported the first successful case of a deceased donor fresh tissue parathyroid allotransplant with immunosuppression in a transplant-naive recipient, the purpose of this study is to further assess the safety and efficacy of this procedure in patients with severe intractable post-surgical hypoparathyroidism.
CONDITIONS
Official Title
Parathyroid Allotransplant for Severe Refractory Hypoparathyroidism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Prior total thyroidectomy
- Symptomatic hypocalcemia requiring daily high dose calcium (>2000 mg) and vitamin D (>2 mcg calcitriol) supplements or intermittent IV calcium
- Biochemical blood tests confirming hypoparathyroidism
- Persistent symptoms and biochemical disease after more than 1 year of medical treatment
- Meets standard organ transplant criteria with no active infection, malignancy, or contraindications to immunosuppression or surgery
You will not qualify if you...
- Under 18 years old
- Current pregnancy
- Advanced stage 3-4 thyroid cancer
- Contraindications to surgery or immunosuppression
- Active malignancies that contraindicate transplant, except certain treated cancers or those in remission
- Malignancies requiring a minimal time from treatment as per transplant consensus guidelines
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Health Network
Toronto, Ontario, Canada, M5S1B2
Actively Recruiting
Research Team
K
Karen Devon, MD, MSc, FRCSC, FACS
CONTACT
E
Esther Lee, BScN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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