Actively Recruiting
Parathyroidectomy After Kidney Transplantation
Led by Aarhus University Hospital · Updated on 2026-02-17
85
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
Sponsors
A
Aarhus University Hospital
Lead Sponsor
U
University of Aarhus
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to clarify whether surgical treatment of persistent hyperparathyroidism after kidney transplantation offers clinically meaningful benefits compared with a conservative treatment strategy. Kidney transplant recipients (\>6 mo after transplantation) with persistent hyperparathyroidism (elevated PTH and either hypercalcemia or hypophosphatemia) will be randomized in a 1:1 ratio to either subtotal parathyroidectomy or conservative management according to standard clinical practice. The study is conducted as an open-label, randomized controlled pilot trial with a 12-month follow-up period. Outcomes include bone density, physical function, quality of life and symptom burden.
CONDITIONS
Official Title
Parathyroidectomy After Kidney Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years and legally competent to understand Danish
- Kidney transplantation at least 6 months ago with no upper time limit
- Stable kidney graft function with estimated GFR ≥ 30 ml/min/1.73m2
- Two consecutive tests showing PTH ≥ 1.5 times normal and either ionized calcium ≥ 1.35 mmol/L or albumin-corrected calcium ≥ 2.70 mmol/L or phosphate ≤ 0.50 mmol/L
You will not qualify if you...
- Unable to provide written, informed consent
- Currently receiving anti-resorptive therapy (bisphosphonate, denosumab)
- Currently receiving bone anabolic therapy (teriparatide, romosozumab)
- Previous parathyroidectomy surgery
- Not fit for surgery, including pregnancy
- Ionized calcium ≥ 1.50 mmol/L or albumin-corrected calcium ≥ 3.00 mmol/L despite stopping calcium supplements
AI-Screening
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Trial Site Locations
Total: 1 location
1
Departement of Nephrology, Aarhus University hospital
Aarhus, Central Jutland, Denmark, 8200
Actively Recruiting
Research Team
H
Hanne S Jørgensen, MD, PhD
CONTACT
A
Amal Derai, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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