Rescuing Mobility Function Through Surgical Removal of the Parathyroid Gland

What this Trial Is About

Researchers are evaluating whether surgical removal of the parathyroid gland (parathyroidectomy) improves physical function and mobility in older adults aged 60 and above with primary hyperparathyroidism (PHPT). PHPT is a common endocrine disorder in older adults that is linked to lower muscle strength, reduced mobility, and poorer quality of life. This prospective observational study aims to better understand changes in physical function and activity after surgery and to identify biomarkers that could predict improvements in mobility. Participants in this study are adults aged 60 or older undergoing parathyroidectomy at UF Health. The study involves physical performance tests, wearing an Actigraph device to monitor physical activity, and providing blood samples for biomarker analysis. These assessments occur before surgery, and at 2 weeks, 3 months, and 6 months post-operation. The goal is to collect detailed data on physical function and biological markers over time. During the study, participants will complete a series of tests including the six-minute walk test, strength measurements, physical activity monitoring, and symptom questionnaires at pre-operative and 3-month post-operative visits. Blood samples are collected at four time points to measure plasma cytokine biomarkers. Researchers will monitor physical activity intensity, frequency, and duration using wearable devices. The total involvement spans several months with multiple assessments to track changes following surgery and safety monitoring throughout.

Parathyroidectomy and Mobility Study