Actively Recruiting
Parathyroidectomy and Mobility Study
Led by University of Florida · Updated on 2025-09-29
80
Participants Needed
1
Research Sites
84 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study evaluates whether surgical removal of the parathyroid gland (parathyroidectomy) improves physical function and mobility in older adults with primary hyperparathyroidism (PHPT). PHPT, a common endocrine disorder in older adults, is associated with reduced muscle strength, mobility, and quality of life. This prospective observational study will enroll up to 80 participants aged 60 and older undergoing parathyroidectomy at UF Health. Participants will complete physical performance tests, wear an Actigraph device to assess physical activity, and provide blood samples for biomarker analysis at pre- and post-operative time points. The goal is to characterize changes in physical function and activity following surgery and to identify biomarkers that may predict mobility improvements. Findings will help inform future larger-scale studies and could expand surgical indications for PHPT in older adults.
CONDITIONS
Official Title
Parathyroidectomy and Mobility Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 63 60 years
- Biochemical diagnosis of hypercalcemic primary hyperparathyroidism confirmed by a specialist
- Scheduled for parathyroidectomy at UF Health
- Willing and able to provide informed consent
You will not qualify if you...
- Unable or unwilling to provide informed consent
- Diagnosis of eucalcemic primary hyperparathyroidism
- Choosing not to have parathyroidectomy at UF Health
- Recent major surgery or hip/knee replacement within 6 months
- Fractures of hands, arms, or legs within last 6 months
- Traumatic accident causing orthopedic trauma or immobilization over 2 weeks within last 6 months
- Blood transfusion within past 3 months
- Heart attack, stroke, or unstable angina within past 6 months
- Severe congestive heart failure (NYHA Class 3 or 4)
- Major psychiatric disorders
- Cancer treatment within the past year, except certain low-risk skin or cured cancers
- Kidney failure requiring dialysis
- Use of bone-modifying therapies within 1 month before surgery
- Planning to leave the area permanently within 3 months after surgery
- Vision or hearing impairment that prevents following instructions despite assistive devices
- Participation in another clinical trial or investigational treatment within 30 days before enrollment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Clinical and Translational Research Building
Gainesville, Florida, United States, 32610
Actively Recruiting
Research Team
N
Nevena Stanojevic, Bachelor of Science
CONTACT
A
Aditya Shirali, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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