Actively Recruiting
Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure)
Led by Johns Hopkins University · Updated on 2026-03-27
690
Participants Needed
2
Research Sites
130 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Individual-level, unblinded randomized controlled trial of an 8-week (short arm) or 24-week (extended arm) pulmonary rehabilitation program, relative to standard of care, to prevent post-tuberculosis respiratory morbidity. Randomization will occur in a 1:1:1 ratio at the initiation of treatment.
CONDITIONS
Official Title
Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age at least 18 years
- Microbiologically confirmed pulmonary tuberculosis disease
- Have not completed more than 2 weeks of tuberculosis treatment
- Receiving tuberculosis care at the outpatient clinics at the TB PuRe study sites
- Willing to complete 48 weeks of study evaluations
- Access to a smartphone
You will not qualify if you...
- Modified Medical Research Council score of 0 points (breathlessness only with strenuous exercise)
- Multi or extensively drug-resistant tuberculosis disease
- Extrapulmonary tuberculosis disease without lung involvement
- Tuberculosis meningitis or tuberculosis of the spine
- Symptomatic cardiovascular disease including coronary artery disease, arrhythmias, and congestive heart failure
- Karnofsky Score less than 40 points
- Any medical condition preventing pulmonary rehabilitation such as fractures or pregnancy
- Use of bronchodilators and/or corticosteroids inhaled or otherwise
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Yenepoya (Deemed to be University
Mangalore, India
Actively Recruiting
2
Symbiosis Medical College for Women & Symbiosis University Hospital and Research Center
Pune, India
Actively Recruiting
Research Team
A
Akshay Gupte, PhD MBBS MSPH
CONTACT
J
Jonathan Golub, PhD MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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