Actively Recruiting
Parkinson's Disease Biomarkers in Nerve Cells in the Gut
Led by Weill Medical College of Cornell University · Updated on 2025-06-22
60
Participants Needed
1
Research Sites
282 weeks
Total Duration
On this page
Sponsors
W
Weill Medical College of Cornell University
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Parkinson's disease affects all the nerve cells in the body, including the ones in the gut. The gut contains its own nervous system, the enteric nervous system, and can be thought of as a "second brain". This second brain can reflect what is going on in the actual brain. This study is being done to look for biomarkers, or early indicators of developing Parkinson's disease, in the microbiome and in the gut tissue taken during routine screening colonoscopy. People aged 45 and over who are due for their routine screening colonoscopy are eligible to participate.
CONDITIONS
Official Title
Parkinson's Disease Biomarkers in Nerve Cells in the Gut
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 45-75 years old
- Parkinson's Disease defined by modified UK Parkinson's Disease Society Brain Bank criteria, or at risk for Parkinson's including REM sleep behavior disorder or a first-degree relative with Parkinson's or related disorders
- Related diseases including Lewy Body Dementia and Multiple System Atrophy
- Baseline Hoehn & Yahr score between 1 and 4
- No contraindications to routine screening colonoscopy
- Able to provide informed consent
You will not qualify if you...
- Signs of neurodegenerative diseases other than synucleinopathy
- Diagnosis of primary mitochondrial disorder, epilepsy, stroke, multiple sclerosis, Alzheimer's disease, Progressive Supranuclear Palsy, or Corticobasal syndrome
- Serious medical conditions limiting life expectancy to less than 24 months or poorly controlled severe diseases
- Active cancer or abnormal chest x-ray findings
- Active or untreated gastrointestinal disease
- Unable to stop anti-platelet or anticoagulant medications safely
- Known substance abuse within the last 5 years
- Contraindication to colonoscopy or anesthesia
- Pregnancy
- Any other condition that makes participation unsuitable as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Weill Cornell Medicine
New York, New York, United States, 10021
Actively Recruiting
Research Team
V
Virginia Gao, MD PhD
CONTACT
J
Jacqueline Burre, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here