Actively Recruiting
The Parkinson's Disease Case-Control Study
Led by Westlake University · Updated on 2025-06-13
40
Participants Needed
1
Research Sites
38 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Parkinson's Disease Case-Control Study is a study of healthy volunteers and patients with Parkinson's disease aged 50-75 years living in Hangzhou, China. This study aims to systematically investigate the differences in intestinal fungi between patients and healthy volunteers, find the key strains, and explore the molecular mechanism of Parkinson's disease with multi-omics data. Another aim of this study is to explore the association between intestinal fungi and brain structure and function from the perspective of the gut-brain axis by combining brain image data.
CONDITIONS
Official Title
The Parkinson's Disease Case-Control Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For Parkinson's disease patients: men or women aged 50 to 75 years
- Clinical diagnosis of Parkinson's disease based on MDS criteria
- Must have at least two symptoms among static tremor, bradykinesia, or stiffness, including static tremor or bradykinesia; or asymmetrical resting tremor or bradykinesia
- Able to provide informed consent
- For healthy volunteers: age (±2 years) and sex-matched to Parkinson's disease patients
- Able to provide informed consent
You will not qualify if you...
- For Parkinson's disease patients: atypical or secondary parkinsonism caused by medications or other diseases
- Clinically diagnosed dementia
- Previous MRI showing significant neurological disorders
- Serious illness such as heart failure or malignancy
- Smoking more than 15 cigarettes a day or history of alcohol or drug addiction
- Inflammatory gastrointestinal diseases
- Chronic diseases affecting gut microorganisms like diabetes, cirrhosis, or cardiovascular disease
- Blood or autoimmune disease or use of immunosuppressants in past 3 months
- Antibiotic use within 3 months before sample collection
- Chronic constipation
- For healthy volunteers: first-degree relative with Parkinson's disease
- Current or past significant neurological disorders
- Previous MRI showing significant neurological disorders
- Use of dopamine blockers, metoclopramide, or riserpine in past 6 months
- Inflammatory gastrointestinal diseases
- Smoking more than 15 cigarettes a day or history of alcohol or drug addiction
- Chronic diseases affecting gut microorganisms
- Blood or autoimmune disease or use of immunosuppressants in past 3 months
- Antibiotic use within 3 months before sample collection
- Chronic constipation
- Participation in other clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
J
Ju-Sheng Zheng, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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