Actively Recruiting
Partial Oral Antibiotic Treatment for Bacterial Brain Abscess
Led by Henrik Nielsen · Updated on 2025-01-30
400
Participants Needed
4
Research Sites
407 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators aim to determine if oral antibiotics are clinically acceptable as treatment of brain abscess. Following 2 weeks of standard intravenous antibiotic therapy, half of patients will continue with this treatment for another 4 weeks or longer while the other half will be assigned to oral antibiotics for the remaining duration of treatment.
CONDITIONS
Official Title
Partial Oral Antibiotic Treatment for Bacterial Brain Abscess
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical symptoms (like headache, neurological problems, or fever) and brain imaging (CT or MRI) consistent with brain abscess
- Physician has decided to treat the patient for bacterial brain abscess
- Ability to take and absorb oral medications, including by nasogastric tube
- Received 14 consecutive days of antibiotic therapy for bacterial brain abscess before randomisation
- Expected to continue antibiotic treatment for at least 14 more days after randomisation
- No worsening of symptoms or new neurological symptoms (except seizures) within 5 days before randomisation
You will not qualify if you...
- Expected poor compliance with treatment (e.g., intravenous drug abuse)
- Pregnancy confirmed by positive pregnancy test in women under 50 years
- Treatment for brain abscess caused by tuberculosis, nocardiosis, Pseudomonas, fungi, toxoplasmosis or other CNS parasites
- Brain abscess related to implanted devices (e.g., deep brain stimulators, ventriculo-peritoneal shunts)
- Severe immune system problems requiring biological or chemotherapy, high-dose steroids for 14+ days, uncontrolled HIV/AIDS, blood cancers, or organ transplant
- Other infections requiring intravenous antibiotics for more than 7 days after randomisation
- Previous participation in this trial
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 4 locations
1
Aalborg University Hospital
Aalborg, Denmark
Actively Recruiting
2
Aarhus University Hospital
Aarhus, Denmark
Actively Recruiting
3
Rigshospitalet
Copenhagen, Denmark
Actively Recruiting
4
Odense University Hospital
Odense, Denmark
Actively Recruiting
Research Team
J
Jacob Bodilsen, MD
CONTACT
H
Henrik Nielsen, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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