Pilot Study of Partial Pleurectomy Surgery for Unresectable Pleural Mesothelioma to Improve Symptoms and Survival

What this Trial Is About

This research investigates whether partial pleurectomy surgery can help relieve symptoms in people with unresectable or borderline resectable pleural mesothelioma, a type of lung cancer that cannot be completely removed. The study also aims to gather information about symptom types, quality of life, complication rates after surgery, time to start other treatments, and overall survival of participants. It is sponsored by the University of Chicago and focuses on patients with confirmed epithelioid subtype pleural mesothelioma confined to one side of the chest. Participants will undergo a partial pleurectomy surgery, which involves removing part of the lining of the lungs. All participants receive the same surgical procedure and study assessments. The research includes pre-surgery evaluation, the surgery itself, and follow-up monitoring. The entire participation period lasts about two years, during which the research team will collect data on symptoms, complications, and treatment timelines. During the study, participants will complete questionnaires about their symptoms at specific times after surgery. Researchers will monitor disease-related symptom burden three months post-surgery and assess quality of life, complication rates, time to resume systemic therapy, and overall survival over two years. All personal information is kept confidential and used solely for research purposes.

Partial Pleurectomy (Surgery) for Unresectable Pleural Mesothelioma