Actively Recruiting

Phase Not Applicable
Age: 18Years - 75Years
All Genders
ID06644066

Study of Partial Pressure of Oxygen Control Method to Quickly Identify the Intersegmental Plane During Lung Surgery for Early Lung Cancer A Prospective, Randomized Controlled Trial Comparing This Method with the Traditional Inflation-Deflation Technique

Led by Tang-Du Hospital · Updated on 2025-01-07

60

Participants Needed

1

Research Sites

34 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating a new method called the Partial Pressure of Oxygen Control method to quickly identify the intersegmental plane (ISP) during anatomical sublobar resection for lung cancer. This study focuses on patients with early non-small cell lung cancer (NSCLC) who have small tumors detected by CT screening. The goal is to compare this new method with the traditional modified inflation-deflation method to see if it can reduce the time needed to find the ISP and improve safety and effectiveness during surgery. The study involves using the Partial Pressure of Oxygen Control method during surgery, which lowers the oxygen levels in the blood to speed up the appearance of the ISP while inflating and deflating the lung. This method is compared to the standard approach to determine if it can shorten the waiting time and provide clearer delineation of the ISP, which is important for preserving lung function. The study is prospective, randomized, and controlled to ensure reliable results. Participants will be monitored throughout the surgical period, with researchers measuring the time it takes to identify the ISP and the lung collapse score. The study includes patients aged 18 to 75 years with specific lung tumor characteristics and good overall health status. Safety is closely observed by tracking oxygen levels during one-lung ventilation, and patients' ability to follow the visit plan and research protocols is required for participation.

CONDITIONS

Official Title

Partial Pressure of Oxygen Control Method in Identification of Intersegmental Plane

Who Can Participate

Age: 18Years - 75Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Between the ages of 18 and 75
  • Any gender
  • Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0-1
  • Thin slice CT showing maximum tumor diameter of 2.0 cm or less and Consolidation Tumor Ratio (CTR) between 0 and less than 1.0
  • Willing and able to voluntarily sign informed consent and comply with study visit plan and protocols
Not Eligible

You will not qualify if you...

  • History of lung surgery
  • Diagnosis of interstitial pneumonia, pulmonary alveoli, pulmonary fibrosis, or severe emphysema
  • Undergoing chest surgery for other reasons or if surgical plan changes during operation
  • Unable or unwilling to understand, cooperate, or sign informed consent regarding the study protocol

AI-Screening

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Trial Site Locations

Total: 1 location

1

The Second Affiliated Hospital of the Air Force Medical University of PLA

Xi'an, Shaanxi, China, 710000

Actively Recruiting

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Research Team

X

Xiaolong Yan, MD

M

Mingliang Xing

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Published Research Related To This Trial

Partial pressure of oxygen control versus modified inflation-deflation method in identifying intersegmental plane during anatomical sublobectomy: a prospective, randomized, controlled trial.

Mingliang Xing, Liping Tong, Hongtao Duan...

https://pubmed.ncbi.nlm.nih.gov/40083504