Actively Recruiting

Phase Not Applicable
Age: 45Years +
MALE
NCT03246802

Partial Prostate Salvage High Dose Rate Brachytherapy

Led by British Columbia Cancer Agency · Updated on 2026-02-02

30

Participants Needed

1

Research Sites

991 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

A dose-response relationship for radiation in the management of prostate cancer is well established. Local recurrence of prostate cancer after external beam radiotherapy occurs in at least 40% of patients treated because of inability to deliver sufficient dose through external beam techniques. These patients respond well to re-irradiation using brachytherapy with about 50% of selected patients remaining free of recurrence 5 years after salvage. Advanced imaging using multiparametric Magnetic Resonance Imaging (mpMRI) allows identification of the site of recurrence, permitting partial prostate salvage brachytherapy. There is extensive literature on Low Dose Rate salvage brachytherapy but less on High Dose Rate.

CONDITIONS

Official Title

Partial Prostate Salvage High Dose Rate Brachytherapy

Who Can Participate

Age: 45Years +
MALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Male aged over 45 years with life expectancy greater than 10 years
  • Previous external beam radiotherapy up to specified doses or low dose rate brachytherapy with recurrence in an under-treated area
  • At least 3 years since prior radiotherapy
  • No late toxicity from prior radiotherapy of grade 2 or higher
  • Rising PSA above nadir + 2 ng/ml but less than 10 ng/ml
  • PSA doubling time longer than 6 months
  • Negative staging scans including CT abdomen/pelvis and bone scan or PSMA PET scan
  • Able to undergo multiparametric MRI with endorectal coil
  • Radiographic evidence of a single dominant intraprostatic lesion
  • Biopsy confirmation of the lesion reviewed by specialized pathologist
  • Able and willing to provide informed consent
  • History and physical exam within 90 days before registration
  • ECOG performance status 0-1
  • International Prostate Symptom Score less than 16 or adequate voiding study results
  • No prior transurethral prostatic resection
  • Lesion suitable for HDR brachytherapy implant with planning target volume ideally less than 65% of prostate volume
  • No history of inflammatory bowel disease or previous rectal surgery
  • Suitable for anesthesia (spinal or general)
  • INR less than 2.5 and platelet count above 75 x 10^9/L
  • Androgen deprivation therapy may be used at oncologist's discretion
Not Eligible

You will not qualify if you...

  • Failure to meet all inclusion criteria
  • Unable to provide informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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3
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Trial Site Locations

Total: 1 location

1

BCCA Center for the Southern Interior

Kelowna, British Columbia, Canada, V1Y 5L3

Actively Recruiting

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Research Team

J

Juanita Crook, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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Partial Prostate Salvage High Dose Rate Brachytherapy | DecenTrialz