Actively Recruiting
Particulate Versus Non-Particulate Corticosteroid in Sacroiliac Joint Injection: A Randomized Prospective Study
Led by University of New Mexico · Updated on 2025-11-06
230
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are comparing two types of corticosteroids, dexamethasone and methylprednisolone, used in sacroiliac (SI) joint injections to treat SI joint pain. The study aims to evaluate and compare the effectiveness and safety of these two medications for people with diagnosed SI joint dysfunction. Participants will be randomly assigned to receive one of these treatments to better understand their impact on pain relief. Participants will be divided into two groups. One group will receive an injection of dexamethasone combined with lidocaine to one or both SI joints, and the other group will receive methylprednisolone with lidocaine in a similar manner. If pain initially improves but then returns, participants may receive a second injection with the same medication and dose. The study includes a three-month follow-up period to observe outcomes after treatment. During the study, participants will report their pain immediately after the injection to confirm SI joint pain and will be followed regularly for three months. Researchers will assess pain levels using a Numeric Pain Rating Score and monitor any side effects or safety concerns. Participants must attend all planned follow-up visits and complete outcome assessments to help compare how each medication works over time.
CONDITIONS
Brief Title
Particulate vs. Non-Particulate Steroid for Sacroiliac Joint Injection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged over 18 and able to understand and provide consent in English
- Able to comply with the study assessments and attend all follow-up visits
- Unilateral low back or buttocks pain lasting at least 2 weeks
- Average pain score of at least 5 out of 10 over the past 7 days
- Diagnosed with sacroiliac joint pain by a board certified Physiatrist with at least 2 positive physical exam findings
- Consent to sacroiliac joint corticosteroid injection
- Experience at least 80% relief of pain within 5 to 15 minutes after injection
You will not qualify if you...
- Clinical suspicion of another cause greater than sacroiliac joint pain
- Receiving disability or worker's compensation for pain treatment
- Involved in active litigation related to pain
- Unable to read English or complete assessments
- Unable to attend follow-up appointments
- Currently incarcerated
- History of prior sacroiliac joint fusion
- Progressive lower extremity neurologic deficits
- Sacroiliac joint steroid injection within the past 12 months
- Two positive lumbar medial branch blocks in past 12 months
- Lumbar radiofrequency ablation within past 12 months
- Lumbar facet steroid injections within past 12 months
- Epidural steroid injection anywhere in spine within past 3 months
- Possible pregnancy or contraindication for fluoroscopy
- Allergy to steroids, contrast media, or local anesthetics
- Body mass index over 40
- Systemic inflammatory arthritis such as rheumatoid arthritis or lupus
- Active infection or antibiotic treatment within past 7 days
- Serious medical disabilities like stroke or heart failure
- Chronic widespread pain or somatoform disorders
- Addictive behavior, severe depression, or psychotic features
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 months
Participants receive an injection of either dexamethasone or methylprednisolone with lidocaine into the sacroiliac joint to treat pain. If pain returns after initial relief, a second injection with the same medication and dose may be offered.
1 initial injection visit and additional visit if a second injection is needed
Duration - 3 months
Participants report their pain levels and are monitored for safety and treatment efficacy after the injections.
Regular follow-up visits during the 3 months after treatment
Trial Site Locations
Total: 1 location
1
University of New Mexico Hospital
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
Research Team
M
Mark W Shilling, BS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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