Actively Recruiting
Passive Stretching in Peripheral Arterial Disease Patients
Led by University of Wisconsin, La Crosse · Updated on 2025-04-02
64
Participants Needed
1
Research Sites
293 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Peripheral artery disease (PAD) leads to higher mortality rates and strains healthcare systems due to increased costs. It causes leg pain during walking due to reduced blood flow. Nitric oxide (NO) deficiency contributes to vascular issues in PAD, with few effective treatments available. Passive calf muscle stretching boosts NO levels, vascular health, and walking ability in PAD patients. However, the inflammatory processes underlying these improvements are unclear. This study aims to track inflammatory markers and cardiovascular changes during 12 weeks of passive stretching. Additionally, combining stretching with dietary nitrate could further enhance walking capacity by reducing reactive oxygen species. The study will monitor inflammation, vascular function, and oxidative capacity to understand the effects on functional ability in PAD patients. This research is crucial for improving physical function and addressing exercise intolerance in PAD.
CONDITIONS
Official Title
Passive Stretching in Peripheral Arterial Disease Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ankle-brachial index of 0.90 or less
- Stable condition for at least 3 months
- Age between 40 and 90 years
You will not qualify if you...
- Habitual exercise or cardiovascular rehabilitation program during the past 3 months
- Critical limb ischemia, amputation, or leg pain at rest
- Major surgery or lower extremity revascularization in the last 3 months
- Heart failure
- Kidney disease
- Beet allergy
- Crohn's disease
- Current smoker
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Wisconsin La Crosse
La Crosse, Wisconsin, United States, 54650
Actively Recruiting
Research Team
J
Jacob T Caldwell, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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