Actively Recruiting
PATCHVALVE: Endobronchial Valves Plus Blood Patch for Persistent Air Leaks
Led by Beth Israel Deaconess Medical Center · Updated on 2025-09-22
20
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to evaluate the real-world safety and effectiveness of combining endobronchial valve (IBV) placement with endobronchial blood patching (EBP) for the treatment of persistent air leaks (PALs) in adult patients undergoing bronchoscopy. PALs are a challenging condition often associated with prolonged hospital stays, increased morbidity, and delayed recovery. The main questions this study aims to answer are: * Does the combination of endobronchial valve placement and endobronchial blood patching accelerate resolution of persistent air leaks? * What are the procedural outcomes, complications, and hospital-related metrics (e.g., chest tube duration, length of stay, and readmission rates) associated with this technique? Participants will: * Undergo standard-of-care bronchoscopy with identification of air leak source. * Receive intrabronchial instillation of autologous blood and tranexamic acid (TXA) followed by balloon occlusion and endobronchial valve placement. * Be followed for resolution of air leak and post-procedure outcomes through standard inpatient monitoring and data collection.
CONDITIONS
Official Title
PATCHVALVE: Endobronchial Valves Plus Blood Patch for Persistent Air Leaks
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older with persistent air leaks (PALs) from causes such as alveolar-pleural fistulas after lung surgery, trauma, lung disease, or other reasons
- Patients with PALs who are not candidates for surgery or have declined surgery
You will not qualify if you...
- Patients who have had other experimental or investigational treatments for persistent air leaks that might affect study results
- Patients who cannot safely undergo bronchoscopy due to severe cardiovascular instability or other medical reasons
- Patients with bronchopleural fistula
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beth Isreal Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
J
Jason Beattie, MD
CONTACT
C
Christine Conley, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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