Actively Recruiting
The Pathogenesis and Natural History of Sjogren's Disease
Led by National Institute of Dental and Craniofacial Research (NIDCR) · Updated on 2026-04-20
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: -Sjogren s Disease (formerly: Sjogrens Syndrome, Sj(SqrRoot)(Delta)gren s syndrome) is a disease that affects about 1-4 million Americans. It is more common in women. It mainly affects the glands that produce saliva and tears, leading to dry eyes and dry mouth. The cause of Sjogren s Disease is unknown, but inflammation plays an important role. The purpose of this study is to learn more about Sjogren s Disease. Objectives: -To better understand how Sjogren s Disease begins and how it affects patients so that we can develop better ways to treat them. Eligibility: * Participants must be 16 years of age or older. * They must have a diagnosis of Sjogren s Disease or have at least two symptoms of Sjogren s Disease. Design: * People taking part in the study will come to the NIH Clinical Center for at least three visits. * During these visits, participants will have a medical history and physical exam. They will have oral and dental assessments, and saliva collection. Lab tests (blood and urine) and dry eye exams will be done. Participants will answer questionnaires and have salivary scintigraphy (adults only unless required for diagnosis). * Other optional tests may also be done. Participants may have to come in for additional visits if they have these optional tests or if their disease changes. * The only treatment provided as part of this study is for medical emergencies or complications that occur while you are at NIH for evaluation.
CONDITIONS
Official Title
The Pathogenesis and Natural History of Sjogren's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to sign informed consent form
- Diagnosis of Sjogren's Disease defined by European-American classification criteria for primary or secondary Sjogren's Disease
- Participants excluded from the European-American criteria due to a comorbid condition but otherwise meeting these criteria
- Incomplete Sjogren's Disease with at least two criteria or common manifestations such as fatigue, vasculitis, arthritis, or autonomic dysfunction not explained by other conditions
- Participants aged 16 years or older
You will not qualify if you...
- Age under 16 years
- Inability or unwillingness to comply with follow-up requirements
- Any medical or psychological condition or treatment that would exclude the subject from research, as judged by the Principal Investigator
- NIH employees who report directly to or are relatives or coworkers of the Principal Investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
E
Eileen M Pelayo
CONTACT
Z
Zohreh Khavandgar, D.D.S.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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