Actively Recruiting
Pathogenesis of Postoperative Infections and Biomarkers for Early Diagnosis of it
Led by National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos · Updated on 2024-08-01
200
Participants Needed
2
Research Sites
252 weeks
Total Duration
On this page
Sponsors
N
National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Lead Sponsor
V
Vilnius University Hospital Santaros Klinikos
Collaborating Sponsor
AI-Summary
What this Trial Is About
Infections remain a prevalent complication after major abdominal surgery. The common belief that most surgical site infections (SSIs) following elective surgery with modern antiseptic techniques are due to intraoperative contamination is still not confirmed. Therefore, alternative mechanisms for SSI development, such as the Trojan Horse theory-which suggests that pathogens from distant sites like the gastrointestinal tract may cause postoperative infections-should be explored. This study aims to analyze the preoperative microbiome of surgical patients' gut and oral cavities and assess whether microorganisms found there are present at the infection site. Additionally, this study will investigate a panel of biomarkers for predicting postoperative infections.
CONDITIONS
Official Title
Pathogenesis of Postoperative Infections and Biomarkers for Early Diagnosis of it
Who Can Participate
Eligibility Criteria
You may qualify if you...
- The patient is scheduled to undergo a major resection-type abdominal surgery due to cancer of the esophagus, stomach, pancreas, liver, bile ducts, colon or rectum.
- Patient is willing to participate.
- Age �3E�3D 18 years.
You will not qualify if you...
- Pregnancy.
- Previous surgical resection of the digestive tract, excluding appendectomy and/or cholecystectomy.
- Anticipated operation with preventive ileostomy.
- The operation is planned to be performed as a matter of urgency.
- Antibiotic therapy within 1 month before surgery.
- Chronic inflammatory bowel disease (non-specific ulcerative colitis, Crohn's disease) or radiation or other colitis of origin.
- During the last year, the patient suffered from Cl. difficile colitis or was Cl. difficile carrier, had salmonellosis or other intestinal infections.
- During the last year, the patient used (> 3 months) pre-/pro-/(syn)biotics.
- During the last year, the patient has been taking proton pump inhibitors continuously (> 6 months).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
National Cancer Institute
Vilnius, Lithuania
Actively Recruiting
2
Vilnius University hospital Santaros Klinikos
Vilnius, Lithuania
Actively Recruiting
Research Team
A
Augustinas Bausys
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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