Actively Recruiting
Pathogenic Variants in Genes Associated With Lung Adenocarcinoma
Led by Oscar Gerardo Arrieta Rodríguez · Updated on 2026-04-08
332
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to describe the prevalence of germ line-pathogenic variants in Mexican patients with lung adenocarcinoma. The main questions it aims to answer are: 1. What is the prevalence of pathogenic variants in genes associated with lung adenocarcinoma in Mexican patients younger than fifty? 2. Which clinical-pathological characteristics are associated with germ-line pathogenic variants in patients with lung adenocarcinoma? 3. How actionable somatic mutations are associated with germ line-pathogenic variants of patients with lung adenocarcinoma? Participants will be asked to sign an informed consent; after that, they will be instructed to donate 10 ml of peripheral blood by venipuncture in the morning and before the patient has taken morning medication and the first meal, following a period of 8-12 hr fasting.
CONDITIONS
Official Title
Pathogenic Variants in Genes Associated With Lung Adenocarcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Both sexes
- Age 16 years or older according to institutional protocols
- Histologically confirmed lung adenocarcinoma (LUAD)
- Signed written informed consent form
- Life expectancy greater than 8 weeks
- Histologically confirmed LUAD plus one of the following: i) Lung cancer family history (one first-degree or two second-degree relatives with lung cancer)
- Age at diagnosis 50 years or younger, or 60 years or younger with a pack-years smoking index
- Presence of at least one actionable genetic alteration (EGFR, ALK, ROS1, KRAS, BRAF, MET exon 14 skipping, or RET)
You will not qualify if you...
- Peripheral blood sample is not accessible
- Insufficient clinical pathological information in electronic clinical records
AI-Screening
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Trial Site Locations
Total: 1 location
1
Thoracic Oncology Unit and Personalized Medicine Laboratory, Instituto Nacional de Cancerología
Mexico City, Mexico City, Mexico, 14080
Actively Recruiting
Research Team
O
Oscar G Arrieta Rodriguez, M.D., M.Sc.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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