Studying Blood and Immune Changes After Severe Trauma and Sepsis Comparing Trauma Patients and Elective Hip Repair Patients

What this Trial Is About

Researchers are studying how severe trauma injuries affect blood cells and the immune system. The study aims to understand if trauma changes the development of blood stem cells and causes immunosuppression that may increase the risk of infections like sepsis during hospital stays. They will compare trauma patients with patients undergoing elective hip repair to see differences in immune response and blood cell behavior. Participants will provide blood samples and a bone marrow sample during surgery for their traumatic injury or elective hip repair. Blood samples will also be collected at surgery, day 14 or hospital discharge, and at 3 and 6 months after surgery. Participants will complete surveys and questionnaires to assess health, quality of life, daily activities, and mobility. Physical function tests such as hand grip strength and a short physical performance battery will be done, along with telephone follow-up at 12 months. Throughout the study, researchers will collect medical record data including vital signs, medications, infections, and treatment outcomes. Participants will be monitored for changes in immune cells and risk of sepsis. The main outcome is to test whether trauma leads to immunosuppressive changes in bone marrow stem cells that increase sepsis risk. The study will last about 12 months, with multiple assessments during recovery to track health and immune function over time.

Pathological Myeloid Activation After Sepsis and Trauma