Studying Causes of Arrhythmias and Reduced Exercise Ability in Adults with Tetralogy of Fallot and Other Congenital Heart Diseases

What this Trial Is About

Researchers are studying the causes behind symptoms like shortness of breath and palpitations, as well as changes in heart structure, in adults with congenital heart disease such as Tetralogy of Fallot and other related heart conditions. The study aims to better understand how these symptoms and heart changes develop over time. This observational study is sponsored by Mayo Clinic and focuses on the mechanisms that contribute to these health issues. Participants will undergo remote heart rhythm monitoring for 30 days at the start of the study, and again at 12 and 24 months. This monitoring is used to see if it can help identify early signs of adverse cardiac events. The study observes heart remodeling and measures aerobic capacity and the occurrence of arrhythmias over a 24-month period. During the study, participants will be assessed for right heart remodeling, incident arrhythmias, and aerobic capacity at scheduled intervals. The remote heart rhythm monitoring will help track heart activity continuously during monitoring periods. The total participation duration is 24 months, with evaluations designed to monitor heart function and symptoms related to congenital heart disease over time.

Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases