Actively Recruiting
Pathophysiological Endotyping Using Baseline Polysomnography Data
Led by University Hospital, Antwerp · Updated on 2025-02-13
1000
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Antwerp
Lead Sponsor
U
Universiteit Antwerpen
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study is designed to develop models to predict site of collapse information using routine polysomnography. In an observational study, the investigators will study 1000 patients with obstructive sleep apnea (OSA) who have had a recent polysomnographic study and will undergo drug-induced sleep endoscopy (DISE) as part of their standard clinical care. Flow shape information from the polysomnographic study will be associated with the DISE results, and a set of prediction models will be developed and validated to detect the site, pattern and degree of upper airway collapse as seen during DISE.
CONDITIONS
Official Title
Pathophysiological Endotyping Using Baseline Polysomnography Data
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older
- Diagnosis of obstructive sleep apnea with apnea-hypopnea index (AHI) of 5 or greater
- Eligible for drug-induced sleep endoscopy as the next clinical step for OSA
- Able to provide informed consent
You will not qualify if you...
- Polysomnography data not available at Antwerp University Hospital
- Unstable clinical status or conditions preventing drug-induced sleep endoscopy
- Use of medications related to sleeping disorders
- Central sleep apnea syndrome
- Medical history of severe daytime tiredness causes or sleep disruptions such as insomnia, periodic limb movements during sleep, or narcolepsy
- Seizure disorders
- Known intellectual disability, memory disorders, or current psychiatric disorders including psychotic illness, major depression, or acute anxiety attacks
- Pregnancy or planning to become pregnant
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Antwerp University Hospital
Edegem, Belgium, 2650
Actively Recruiting
Research Team
S
Sara Op de Beeck, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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