Actively Recruiting
Pathophysiology, Psycho-emotional and Cognitive Functioning Associated With Tinnitus
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2024-12-12
300
Participants Needed
2
Research Sites
408 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
the investigators have recently shown that patients with drug-resistant temporal lobe epilepsy who have undergone brain surgery targeting the medial temporal lobe structures were more likely to develop tinnitus postoperatively. This discovery of a vulnerability to tinnitus associated with medial temporal lobe surgery to eliminate drug-refractory epileptic seizures provides a new clinical model of tinnitus, targeting temporal lobe regions as generators or mediators of this hearing disorder. The objective of this project is to study the impact of tinnitus on the cognitive, emotional, psychoacoustic and cerebral functioning associated with this hearing disorder, and to clarify the pathophysiology of tinnitus by comparing different groups of individuals with tinnitus (surgical epileptic patients or non-surgical ORL patients) to matched tinnitus-free groups (surgical tinnitus-free cases and healthy controls volunteer).
CONDITIONS
Official Title
Pathophysiology, Psycho-emotional and Cognitive Functioning Associated With Tinnitus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �38 years old
- Good written and oral comprehension of the French language
- Person affiliated to a Social Security scheme
- Informed consent signed by the participant
- Normal or corrected vision
- Absence of known pre-existing neurological and/or degenerative disorders
- Suffering from subjective uni- or bilateral tinnitus, chronic (>3 months) and stable (no period of remission) for Tinnitus+ Group
- Surgically treated for drug-resistant epilepsy of the temporal lobe (including the amygdala) for Chir+ Group
- Not suffering from tinnitus for Group Tinnitus-
- Non epileptic for Group Chir-
- Not having undergone surgical treatment of the temporal lobe (including the tonsil) for Group Chir-
You will not qualify if you...
- Presence of severe or profound deafness, uni or bilateral
- Under legal protection (guardianship, curators, etc.)
- MRI contraindicated or claustrophobic for patients completing visit V2
- Pregnant or breastfeeding woman for patients completing visit V2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Service de Soins de Suite et Réadaptation (SSR) Neurologique, DMU de Neurosciences
Paris, France, 75013
Actively Recruiting
2
Hôpital Européen Georges Pompidou
Paris, France, 75015
Actively Recruiting
Research Team
S
Sophie DUPONT, MD, Ph.D
CONTACT
S
Séverine Samson, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here