Actively Recruiting
PathToScale: The PERSIST Trial
Led by Georgetown University · Updated on 2026-03-04
9900
Participants Needed
1
Research Sites
36 weeks
Total Duration
On this page
Sponsors
G
Georgetown University
Lead Sponsor
C
Center for the Development of People
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to identify the effectiveness of a bundle of strategies to support continuation of clients on pre-exposure prophylaxis, including long-acting injectable cabotegravir and oral pre-exposure prophylaxis to high priority groups.
CONDITIONS
Official Title
PathToScale: The PERSIST Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals aged 15 years or older
- Female sex workers
- Men who have sex with men
- Transgender individuals
- Women, adolescent girls, and young women attending STI, family planning, or HIV testing services
- Breastfeeding women
- Male partners of female sex workers, men at high risk for HIV, or men with syndromic or lab-confirmed sexually transmitted infections
- Individuals initiated on long-acting injectable cabotegravir for PrEP aged 15 years or above
You will not qualify if you...
- Living with HIV-1 or showing signs of possible acute HIV infection
- Prior diagnosis of Hepatitis B
- Known severe side effects to long-acting cabotegravir
- Unwilling or unable to return for 3-monthly HIV testing or 2-monthly counseling and safety monitoring visits
- Currently on multi-drug resistant tuberculosis medications
- Currently taking post-exposure prophylaxis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Community Health Science Unit
Lilongwe, Malawi
Actively Recruiting
Research Team
C
Charles Holmes, MD, MPH
CONTACT
D
Deborah Hoege, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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