Actively Recruiting
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment
Led by Laurie McLouth · Updated on 2026-05-08
234
Participants Needed
1
Research Sites
226 weeks
Total Duration
On this page
Sponsors
L
Laurie McLouth
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will compare the effects of a brief supportive intervention, called Pathways, against enhanced usual care on the mental health and quality of life of people undergoing treatment for advanced lung cancer. Patients will complete baseline survey measures and be randomized to intervention. Survey measures will be collected again mid-intervention, post-intervention and at 6- and 12-week follow-up, with analyses focused on changes pre- to post-intervention.
CONDITIONS
Official Title
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- New or recurrent AJCC 8th edition stage 3b, 3c, or IV non-small cell lung cancer, extensive stage small cell lung cancer
- 18 years of age or older
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2 or Karnofsky score 60-100
- Currently 3 to 12 weeks into systemic, infusion-based treatment (chemotherapy, immunotherapy, chemo-immunotherapy)
- Past month distress score of 3/10 or higher or a Rotterdam Symptom item score of 2 or higher for psychological distress items
You will not qualify if you...
- Unstable brain metastases causing progressive neurological deficits, uncontrolled seizures, or needing increased steroid doses
- Cognitive conditions like dementia or psychiatric disorders such as psychosis that make participation inappropriate
- Receiving overlapping palliative care or psychological services at the cancer center
- Unable to speak and read English
- Hearing or visual impairments that prevent study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Kentucky
Lexington, Kentucky, United States, 40506
Actively Recruiting
Research Team
L
Laurie McLouth, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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