Study on Brain Stimulation and Memory in Adults 55 and Older with Mild Cognitive Impairment and History of Mild Traumatic Brain Injury

What this Trial Is About

Researchers are investigating whether biological changes in people with amnestic mild cognitive impairment aMCI are linked to a history of mild traumatic brain injury mTBI. This study includes participants both with and without a history of mTBI to explore these potential connections using specialized brain stimulation and blood tests. The trial is a phase 2 interventional study that aims to better understand these relationships through diagnostic tools. The study uses high definition transcranial direct current stimulation HD-tDCS applied in three different conditions sham control, active stimulation to the frontal brain region, and active stimulation to the left temporal region. Each participant will receive all three conditions in a randomized order, separated by 14 days. Active stimulation involves 2 mA current for 30 minutes over three consecutive days, while sham stimulation mimics this timing but with minimal current. Electrode placement follows a 4x1 ring configuration based on a standard EEG system. Participants will complete ten study visits that include blood draws and memory evaluations before and after each stimulation condition. Memory and cognitive tests like the Rey Auditory Verbal Learning Test and Delis Kaplan Executive Function System assessments will be used to measure changes. The study team will closely monitor participants throughout the sessions, and the entire participation is expected to last across these multiple visits with assessments immediately following each stimulation period.

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History