Actively Recruiting
Patient-centered Dosage of Levothyroxine
Led by University Hospital of North Norway · Updated on 2025-09-10
240
Participants Needed
3
Research Sites
153 weeks
Total Duration
On this page
Sponsors
U
University Hospital of North Norway
Lead Sponsor
S
SINTEF Health Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
Levothyroxine is the most used thyroid hormone replacement when the thyroid gland is failing. Because dosage adjustment normally takes several months, the investigators have developed a decision support tool (DST) that predicts optimal dosage based on repeated blood samples the first 2 weeks after initiation of therapy. In this randomized study the investigators will include patients that start levothyroxine therapy after total thyroidectomy. The use of DST to advice the physician about an early dosage adjustment will be compared with common clinical practice, that is dosage adjustment every 2 months. The effect of DST use will be assessed by studying the possible relationship between fast optimal dose adjustment, patient reported outcome measures, and ability to work.
CONDITIONS
Official Title
Patient-centered Dosage of Levothyroxine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Total or completion thyroidectomy for differentiated thyroid cancer or benign thyroid nodules at Norwegian hospitals
You will not qualify if you...
- Anaplastic thyroid cancer
- Thyroid cancer with distant metastasis
- Graves disease
- Toxic nodules
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Haukeland University Hospital
Bergen, Norway
Actively Recruiting
2
Oslo University Hospital
Oslo, Norway
Actively Recruiting
3
University Hospital of North Norway
Tromsø, Norway, 9010
Actively Recruiting
Research Team
V
Vegard Brun, PhD
CONTACT
S
Solveig Brun, cand.med
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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