COPE-AKI Trial Comparing a Multimodal Care Approach to Usual Care for Adults Hospitalized with Acute Kidney Injury

What this Trial Is About

Researchers are evaluating a new care approach for adults hospitalized with acute kidney injury AKI. This study compares a multimodal intervention to usual care to see if it increases the number of days patients spend out of the hospital within 90 days after discharge. The study also looks at effects on major kidney problems, repeat AKI episodes, and patient-reported health outcomes over up to one year. The intervention includes three parts a study doctor reviews the patient at hospital discharge and makes follow-up recommendations a nurse navigator provides kidney disease education, coordinates care, and monitors symptoms and a pharmacist reviews medications to avoid kidney-harming drugs and ensure proper dosing. Participants in the usual care group receive written information about kidney health and the importance of follow-up but do not get the extra support from the study team. Participants will be monitored through follow-up visits to track hospital-free days over 90 days, rates of major kidney events and recurrent AKI up to 180 and 365 days, and changes in quality of life and social support. The study collects patient-reported outcomes at several time points to understand the impact of the care approach. The total study duration for each participant is about one year, with assessments conducted remotely or in person as needed.

A Patient-centered Trial of a Process-of-care Intervention in Hospitalized AKI Patients: the COPE-AKI Trial