Actively Recruiting
Patient Quality of Recovery After TAVR With Different Sedation Regimens
Led by David Lyubashevsky · Updated on 2026-04-29
126
Participants Needed
1
Research Sites
115 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether the type of sedation medication used during a transcatheter aortic valve replacement (TAVR) affects how people recover after the procedure. The main question this study aims to answer is whether different sedation regimens (propofol, dexmedetomidine, or midazolam with fentanyl) lead to differences in quality of recovery on the first day after the procedure. Researchers will compare three commonly used sedation medications (propofol, dexmedetomidine, or midazolam with fentanyl) to determine whether they lead to differences in recovery following a TAVR. Participants will: * Be enrolled before their scheduled TAVR procedure * Be randomly assigned to receive one of the three sedation medications during their procedure * Complete short surveys on postoperative days 1 and 7 about pain levels, how they feel during their recovery, and how satisfied they were with their anesthesia experience
CONDITIONS
Official Title
Patient Quality of Recovery After TAVR With Different Sedation Regimens
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 90 years inclusive
- Undergoing transfemoral transcatheter aortic valve replacement (TAVR) under monitored anesthesia care
- Able to speak English or Spanish
- Provides consent to participate in the study
You will not qualify if you...
- Preoperative heart rate less than 50 beats per minute or arrhythmias such as atrial fibrillation with rapid ventricular response
- Presence of conduction abnormalities like second or third degree AV block without a pacemaker
- Allergy or contraindication to any of the study drugs (propofol, dexmedetomidine, midazolam, fentanyl)
- Pulmonary artery pressure greater than 70 mmHg
- Morbid obesity with body mass index over 50
- Pregnancy
- Unable to provide consent in English or Spanish
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Endeavor Health
Glenview, Illinois, United States, 60026
Actively Recruiting
Research Team
J
Jessica Brickner
CONTACT
N
Nia Moragne
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here