Actively Recruiting
In-patient SCC TMS
Led by University of California, Los Angeles · Updated on 2025-09-23
30
Participants Needed
1
Research Sites
98 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators are studying the feasibility, safety, and tolerability of administering accelerated repetitive Transcranial magnetic stimulation(a-rTMS) at frequencies other than standard 10 Hz for in-patient Subjects diagnosed with Major Depressive Disorder. Participants will be recruited from the Resnick Neuropsychiatric Hospital. This study will enroll 30 participants who will undergo up to three brain activity recordings, one MRI scan, one TMS procedure to determine the appropriate frequency and intensity for treatment, daily symptom assessments, and 25 TMS treatments. Participants will be asked to participate for up to 2 weeks.
CONDITIONS
Official Title
In-patient SCC TMS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years
- Confirmed moderate to severe Major Depressive Disorder with a HAM-D score of 17 or higher
- No improvement after at least two trials of antidepressant medications
- No improvement after treatments from at least two different medication classes
- Received at least two evidence-based augmentation therapies (benzodiazepines excluded)
- Completed a trial of psychotherapy effective for MDD with adequate frequency and duration
- Willing and able to follow the accelerated treatment schedule
You will not qualify if you...
- Unable to give informed consent due to mental or legal incapacity
- Infection or poor skin condition on the scalp where treatment device will be applied
- Increased seizure risk due to family history, stroke, or medications
- Current psychotic symptoms or diagnosis such as schizophrenia or schizoaffective disorder
- Neurological conditions including epilepsy, cerebrovascular disease, dementia, high intracranial pressure, severe head trauma, or brain tumors
- Presence of implanted magnetic-sensitive medical devices such as pacemakers or cochlear implants (dental fillings are allowed)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UCLA TMS Service and Research Service
Los Angeles, California, United States, 90024
Actively Recruiting
Research Team
N
Nikita Vincecruz, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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