Actively Recruiting
Patient-specific Reconstruction Plate for Segmental Mandibular Defects
Led by Alexandria University · Updated on 2026-01-06
14
Participants Needed
1
Research Sites
86 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The mandible's horseshoe-shaped anatomy makes the reconstruction of segmental defects a challenging procedure. Conventional reconstruction typically relies on alloplastic plates to bridge bony stumps; however, these require extensive intraoperative bending, often resulting in imperfect adaptation, press-to-contact fixation, and residual stresses that increase the risk of hardware fatigue and fracture. Recent advances in computer-aided design and manufacturing (CAD/CAM) and virtual surgical planning (VSP) have improved precision in maxillofacial reconstruction. Patient-Specific Reconstruction Plates (PSRP), developed from virtual planning and patient-specific anatomical data, offer a bespoke contour adaptation, predictable screw positioning, and elimination of press-fit deformation. This customization improves alignment, mechanical stability, and long-term outcomes.
CONDITIONS
Official Title
Patient-specific Reconstruction Plate for Segmental Mandibular Defects
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a segmental mandibular continuity defect, not involving the condyle
- Patients suffering from benign, locally invasive or malignant lesions involving the lower border of the mandible
- Patients with recurrent lesions after resection
- Patients with osteomyelitis or jaw osteonecrosis indicated for sequestrectomy, including Stage-III jaw osteonecrosis
- Patients with traumatic mandibular defects
- Patients with post-gunshot mandibular defects
You will not qualify if you...
- Medically compromised patients who cannot undergo the operation
- Patients with segmental mandibular defects requiring condylar process resection
- Patients with lateral segmental mandibular defects involving the condyle needing alloplastic total joint reconstruction
- Patients with an active infection at the site of resection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Faculty of Dentistry, Alexandria University
Alexandria, Alexandria Governorate, Egypt, 21523
Actively Recruiting
Research Team
Y
yehia A El-Mahallawy., PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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