Actively Recruiting
Patients Derived Organoids in Ovarian Cancer
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-03-04
48
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Among cancer models, patients derived organoids (PDOs) best reproduce tumor's tissue architecture, intratumor heterogeneity and are able to mimic in vivo patients' drugs response. For these reasons, it has been designed a study to assess the feasibility of PDOs immune cells co-culture in OC patients and the concordance between ex vivo sensitivity and in vivo treatment response. If proven effective and reliable, PDOs could be introduced into clinical practice as empirical predictor of patients' response to antineoplastic drugs.
CONDITIONS
Official Title
Patients Derived Organoids in Ovarian Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Preoperative clinical, serological and radiologic suspicion of International Federation of Gynecology and Obstetrics (FIGO) stage IIIC or greater ovarian, fallopian tube, or primary peritoneal cancer
- Histologic diagnoses of epithelial ovarian cancer at frozen section
- Age greater than 18 years
- Estimated life expectancy of at least 4 weeks
- Performance status (PS) according to Eastern Cooperative Oncology Group (ECOG) less than 2
You will not qualify if you...
- Non-serous histology at frozen section
- Diagnosis of immunodeficiency
- Receiving chronic systemic steroid therapy (more than 10 mg equivalent prednisone daily)
- Receiving any other form of immunosuppressive therapy within 7 days prior to enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Policlinico Universitario Agostino Gemelli
Roma, Italy
Actively Recruiting
Research Team
C
Camilla Nero, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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