Actively Recruiting
Patients Derived Organoids as a Promising Tool to Tailor Ovarian Cancer Therapies (PANDORA).
Led by Centro di Riferimento Oncologico - Aviano · Updated on 2024-01-29
150
Participants Needed
1
Research Sites
737 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The association of clinical, pathogenesis and mutational profile of patients affected by ovarian cancer have improved the armamentarium of therapies available for medical doctors. One of most remarkable advancements is represented by the introduction of PARP inhibitors in the front-line setting of advanced ovarian carcinoma. It is necessary to continue with this effort and introduce novel approaches to improve the survival rate as well as predictive biomarkers to approved therapies. Given the absence of predictive biomarkers to standard therapy, patients derived organoid could be a promising platform to test clinically available drugs and/or promising new molecules to explore the tumor sensibility in an ex-vivo model. The aim of this study is to correlate treatment sensibility measured in tumor derived organoids to clinical sensibility seen in real world patients.
CONDITIONS
Official Title
Patients Derived Organoids as a Promising Tool to Tailor Ovarian Cancer Therapies (PANDORA).
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent form
- Female sex
- Age 18 years or older
- Diagnosis of ovarian cancer
- Availability of tumor sample or ascites planned for storage in the Institutional Biobank for research
You will not qualify if you...
- Tumor or ascites biobanking process that could compromise diagnostic assessments
- Pregnancy or breastfeeding
- History of another malignancy within the last 5 years
AI-Screening
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Trial Site Locations
Total: 1 location
1
Centro di Riferimento Oncologico (CRO) di Aviano - IRCCS
Aviano, Pordenone, Italy, 33081
Actively Recruiting
Research Team
V
Vincenzo Canzonieri, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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