Actively Recruiting
Patients Pregnant Women With or Without Primary Antiphospholipid Antibody Syndrome
Led by IRCCS San Raffaele · Updated on 2025-06-18
60
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to evaluate the ability of placental angiogenesis markers to predict the risk of PE in pregnancy in women with primary APS. To construct reference intervals of placental angiogenesis markers specific to women affected by primary APS in pregnancy by measuring the levels of sFlt-1and PlGF in serum maternal serum and their sFlt-1/PlGF ratio during the trimesters of gestation (I TM, II TM and III TM). For this aim the study will involve recruiting two groups of subjects, one will be cases and one will be controls.
CONDITIONS
Official Title
Patients Pregnant Women With or Without Primary Antiphospholipid Antibody Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant patients between the ages of 18 and 45 years with a diagnosis of primary APS according to international classification criteria.
- Pregnant patients between the ages of 18 and 45 years with at least one previous full-term pregnancy and no diagnosis of APS according to international classification criteria.
You will not qualify if you...
- Pregnancies achieved by medically assisted procreation (PMA).
- Known chronic conditions during pregnancy such as chronic essential hypertension or neurological disorders.
- Previous thrombotic events.
- Chronic renal failure not related to autoimmune disease.
- Previous history of cancer.
- For the group without APS, previous history of multiple miscarriages or late pregnancy complications.
AI-Screening
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Trial Site Locations
Total: 1 location
1
San Raffaele Hospital
Milan, Italy
Actively Recruiting
Research Team
P
Patrizia Rovere Querini
CONTACT
V
Valentina Canti
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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