Actively Recruiting
pBFS-guided cTBS at Different Doses for Aphasia After Stroke
Led by Changping Laboratory · Updated on 2025-04-04
60
Participants Needed
2
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this trial is to evaluate the effectiveness and safeness of different doses of continuous Theta Burst Stimulation (cTBS) over the right Superior Frontal Gyrus (SFG), guided by personalized Brain Function Sector (pBFS) technology, on language function recovery in patients with post-stroke aphasia.
CONDITIONS
Official Title
pBFS-guided cTBS at Different Doses for Aphasia After Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 35 and 75 years old, inclusive
- Diagnosed with ischemic or hemorrhagic stroke with lesions in the left hemisphere, with illness duration from 15 days to 6 months
- Diagnosed with aphasia by the Chinese version of Western Aphasia Battery with aphasia quotient below 93.8 points
- First stroke occurrence
- Normal language function before stroke and native Chinese speaker with at least 6 years of education
- Understands the trial and has signed informed consent
You will not qualify if you...
- Combined dysarthria with NIHSS item 10 score of 2 or higher
- Aphasia caused by bilateral hemisphere stroke, brain tumor, traumatic brain injury, Parkinson's disease, motor neuron disease, or other diseases
- Implanted electronic devices such as pacemakers or cochlear implants, or MRI/TMS contraindications
- History of epilepsy
- Severe uncontrolled systemic diseases affecting heart, lungs, liver, kidneys, etc.
- Consciousness disorders with NIHSS 1(a) score of 1 or higher
- Malignant hypertension
- Severe organic diseases like malignant tumors with expected survival less than 1 year
- Severe hearing, visual, or cognitive impairment or inability to cooperate
- Severe depression, anxiety, or mental illnesses preventing trial completion
- Neuromodulation treatments like TMS or transcranial electric stimulation in past 3 months
- History of alcoholism, drug, or other substance abuse
- Other abnormalities deemed unsuitable by researchers
- Inability to complete follow-up due to geographic or other reasons
- Women who are pregnant, breastfeeding, or planning pregnancy during trial
- Currently participating in other clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Nanshi Hospital of Nanyang
Nanyang, Henan, China
Actively Recruiting
2
The fifth Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Actively Recruiting
Research Team
R
Ruiqi Pan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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