Actively Recruiting
pBFS-guided cTBS Over the Superior Temporal Gyrus for Aphasia After Ischemic Stroke
Led by Changping Laboratory · Updated on 2025-04-04
40
Participants Needed
2
Research Sites
145 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this trial is to evaluate the effectiveness and safeness of continuous Theta Burst Stimulation (cTBS) over the right Superior Temporal Gyrus (STG), guided by personalized Brain Function Sector (pBFS) technology, on language function recovery in patients with post-ischemic stroke aphasia.
CONDITIONS
Official Title
pBFS-guided cTBS Over the Superior Temporal Gyrus for Aphasia After Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 35 and 75 years old (inclusive)
- Diagnosed with acute ischemic stroke in the left hemisphere lasting from 15 days to 3 months
- Diagnosed with aphasia using the Chinese version of the Western Aphasia Battery with an aphasia quotient below 93.8
- First stroke occurrence
- Normal language function before stroke and native Chinese speaker with at least 6 years of education
- Able to understand the trial and provide informed consent
You will not qualify if you...
- Severe dysarthria with NIHSS item 10 score of 2 or higher
- Aphasia caused by bilateral stroke, brain tumor, traumatic brain injury, Parkinson's disease, motor neuron disease, or other diseases
- Implanted electronic devices such as pacemakers or cochlear implants, or MRI/TMS contraindications
- History of epilepsy
- Severe uncontrolled systemic diseases affecting heart, lungs, liver, kidneys confirmed by labs
- Consciousness disorders with NIHSS 1(a) score of 1 or higher
- Malignant hypertension
- Severe organic diseases like malignant tumors with expected survival under 1 year
- Severe hearing, visual, or cognitive impairments or inability to cooperate
- Severe depression, anxiety, or mental illness preventing trial completion
- Neuromodulation treatments within 3 months prior to enrollment
- History of alcoholism, drug, or substance abuse
- Other conditions judged unsuitable by researchers
- Unable to complete follow-up due to location or other reasons
- Women of childbearing age who are pregnant, breastfeeding, or planning pregnancy
- Participation in other clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
First Hospital of Jilin University
Changchun, China
Actively Recruiting
2
Shengjing Hospital of China Medical University
Shenyang, China
Actively Recruiting
Research Team
N
Na Xu, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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