Actively Recruiting
pBFS-guided Dual-target cTBS for Aphasia After Stroke
Led by Changping Laboratory · Updated on 2025-04-04
60
Participants Needed
2
Research Sites
122 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this trial is to evaluate the effectiveness and safeness of personalized brain functional sectors (pBFS) technology-guided continuous theta burst stimulation (cTBS) on the inferior frontal gyrus (IFG) combined with the superior temporal gyrus (STG) for language function recovery in post-stroke aphasic patients.
CONDITIONS
Official Title
pBFS-guided Dual-target cTBS for Aphasia After Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 35 and 75 years old, including 35 and 75
- Diagnosed with ischemic or hemorrhagic stroke affecting the left hemisphere, with illness duration between 15 days and 6 months
- Diagnosed with aphasia by the Chinese version of Western Aphasia Battery with a score less than 93.8
- First stroke episode
- Normal language function before stroke onset; native Chinese speaker with at least 6 years of education
- Understand the trial and signed informed consent form
You will not qualify if you...
- Combined dysarthria with NIHSS item 10 score of 2 or more
- Aphasia caused by bilateral stroke, brain tumor, traumatic brain injury, Parkinson's disease, motor neuron disease, or other diseases
- Implanted electronic devices like pacemakers or cochlear implants, metal foreign bodies, or MRI/TMS contraindications
- History of epilepsy
- Severe uncontrolled systemic diseases affecting heart, lungs, liver, kidneys
- Consciousness disorders with NIHSS 1(a) score 1 or more
- Malignant hypertension
- Severe organic diseases or malignant tumors with expected survival less than 1 year
- Severe hearing, visual, cognitive impairments or inability to cooperate
- Severe depression, anxiety, or other mental illnesses preventing trial completion
- Received neuromodulation treatments such as TMS or transcranial electric stimulation in prior 3 months
- History of alcoholism, drug abuse, or other substance abuse
- Other abnormal findings judged unsuitable by researchers
- Unable to complete follow-up due to location or other reasons
- Women who are pregnant, breastfeeding, or planning pregnancy during trial
- Currently participating in other clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Shandong Provincial Hospital
Jinan, Shandong, China
Actively Recruiting
2
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
Actively Recruiting
Research Team
R
Ruiqi Pan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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