Actively Recruiting
pBFS-guided iTBS Over the Left DLPFC for Chronic PSCI
Led by Changping Laboratory · Updated on 2025-06-06
60
Participants Needed
1
Research Sites
110 weeks
Total Duration
On this page
Sponsors
C
Changping Laboratory
Lead Sponsor
C
China Rehabilitation Research Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study aims to investigate the efficacy and safety of intermittent theta burst stimulation (iTBS) guided by the personalized Brain Functional Sector (pBFS) technique in the treatment of patients with chronic post-stroke cognitive impairment.
CONDITIONS
Official Title
pBFS-guided iTBS Over the Left DLPFC for Chronic PSCI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of ischemic or hemorrhagic stroke confirmed by CT or MRI
- Meets diagnostic criteria for post-stroke cognitive impairment
- First stroke occurrence
- Stroke occurred 3 to 12 months prior
- Stroke located in the supratentorial region
- Cognitive dysfunction in at least one domain: executive function, attention, memory, language, or visuospatial ability
- Mild to moderate cognitive impairment: MMSE ≥ 10 and MoCA < 26 or MMSE < 27
- Able to understand the trial and provide informed consent
You will not qualify if you...
- Cognitive impairment from other disorders such as mild cognitive impairment, Alzheimer's disease, vascular dementia, or traumatic brain injury
- History of drug or alcohol abuse
- History of psychiatric disorders or severe depression/anxiety
- Severe diseases in circulatory, respiratory, digestive, urinary, endocrine, or blood systems not controlled by medication
- Malignant hypertension or malignant tumors
- Severe infections or electrolyte/acid-base imbalances
- Severe aphasia, dysarthria, impaired consciousness, audiovisual impairments, or inability to cooperate with assessments
- History of seizures
- Contraindications to TMS treatment (e.g., pacemakers, cochlear implants, metallic implants, electronic devices)
- Contraindications to MRI scanning
- Neuromodulation therapy within past 3 months
- Participation in other clinical trials
- Pregnant or planning pregnancy
- Other abnormalities as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
China Rehabilitation Research Center
Beijing, China
Actively Recruiting
Research Team
K
Kaiyue Han, MD
CONTACT
Y
Ying Zhou
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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