Prophylactic Cranial Irradiation and Brain MRI Follow-up Versus Brain MRI Follow-up Alone in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Complete Remission After Definitive Radio-chemotherapy

What this Trial Is About

Researchers are evaluating the use of prophylactic cranial irradiation (PCI) compared to regular brain MRI follow-up alone in patients with limited-stage small cell lung cancer (SCLC) who have achieved complete remission after definitive thoracic radiotherapy and chemotherapy. The study aims to determine if MRI follow-up alone is not inferior to PCI in preventing brain metastases over two years, as well as differences in overall survival and quality of life between the two approaches. Participants are randomly assigned to one of two groups: the control group receives PCI plus regular brain MRI follow-up, while the study group undergoes regular brain MRI follow-up alone without PCI. The study focuses on patients who have finished their chest radiotherapy and chemotherapy and have shown a complete tumor response. Both interventions are monitored over a period of up to two years. During the study, participants will be regularly monitored with brain MRI scans to assess brain metastasis-free survival and overall survival rates. Researchers will also evaluate intracranial progression patterns and patients' overall quality of life. The study involves follow-up visits and clinical assessments over a two-year timeframe to gather these outcome measures and monitor participant health and safety.

PCI and Brain MRI Follow-up vs Brain MRI Follow-up Alone in Limited-stage SCLC Patients