Actively Recruiting
PDMC Implementation Trial in Kenya
Led by Liverpool School of Tropical Medicine · Updated on 2025-11-21
600
Participants Needed
1
Research Sites
55 weeks
Total Duration
On this page
Sponsors
L
Liverpool School of Tropical Medicine
Lead Sponsor
K
Kenya Medical Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this implementation trial is to evaluate at least two alternative delivery strategies and adherence support for malaria chemoprevention with dihydroartemisinin-piperaquine in the post-discharge management of children hospitalised with severe anaemia or severe malaria to optimise adherence in Kenya. The actual interventions to be evaluated have been co-designed with national stakeholders during an initial formative research stage.
CONDITIONS
Official Title
PDMC Implementation Trial in Kenya
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Health facilities with blood transfusion services offering in-patient care for children with severe anaemia and severe malaria
- At least 40 children admitted per year with severe anaemia or severe malaria
- Agreement to participate by facility management
- Located in areas with moderate to high malaria transmission
- Children younger than 10 years of both sexes
- Hospitalised with severe anaemia (haemoglobin <5.0 g/dL or PCV <15%, or requiring blood transfusion) or severe malaria (requiring parenteral artesunate and/or confirmed Plasmodium infection)
You will not qualify if you...
- Health facilities without subservient lower-level health facilities
- Recognised other causes of severe anaemia such as trauma, haematological malignancy, or known bleeding disorders like haemophilia
- Sickle cell anaemia or sickle cell disease
- Body weight less than 5 kg
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Kemri, Cghr
Kisumu, Kenya, 40 100
Actively Recruiting
Research Team
J
Jenny Hill, MSc, PhD
CONTACT
J
Juliet Otieno, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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