Actively Recruiting

Age: 3Years - 17Years
All Genders
NCT06811935

PEDI Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcus Study

Led by University of Wisconsin, Madison · Updated on 2026-01-27

30

Participants Needed

2

Research Sites

145 weeks

Total Duration

On this page

Sponsors

U

University of Wisconsin, Madison

Lead Sponsor

N

National Institute of Mental Health (NIMH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The objective of the Pediatric Epidemiological Data and Incidence (PEDI) PANDAS study is to demonstrate the feasibility of enrollment and retention of subjects in a study to determine the incidence and natural history of children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) with regard to spectrum, course and outcome. The investigators aim to demonstrate they can recruit and retain 85% of children who are eligible for this study. Eligible children are those who fit criteria for PANS and Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus (PANDAS). Each child will be followed for one year.

CONDITIONS

Official Title

PEDI Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcus Study

Who Can Participate

Age: 3Years - 17Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Child age 3 to 17 years old
  • Child and parent/guardian able to complete all study activities in English
  • Family plans to be followed within UW Health or Dartmouth Health for at least one year
  • Pediatric patient currently in primary care at UW Health or Dartmouth Health (primary care group only)
  • Abrupt onset of symptoms within 7 days, occurring in the past 3 months (primary care group only)
  • Suspected diagnosis of PANS or PANDAS based on published criteria (primary care group only)
  • Abrupt onset of symptoms within 7 days, occurring in the past 4 months (external to primary care group only)
  • Confirmed diagnosis of PANS or PANDAS based on published criteria (external to primary care group only)
Not Eligible

You will not qualify if you...

  • History of tics, OCD, or food restriction/avoidance inconsistent with sudden onset or present before investigation onset
  • Current symptoms of Pica
  • Previous participation in this study
  • Not suitable for study participation as judged by the site investigator (e.g., insufficient verbal or cognitive ability)
  • Patient or family unable to complete study questionnaires or procedures in English as primary language

AI-Screening

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Trial Site Locations

Total: 2 locations

1

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States, 03766

Actively Recruiting

2

UW School of Medicine and Public Health

Madison, Wisconsin, United States, 53792

Actively Recruiting

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Research Team

P

Pediatric Clinical Research Coordination

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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