Actively Recruiting

Phase 1
Phase 2
Age: 0 - 22Years
All Genders
NCT04726241

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

Led by PedAL BCU, LLC · Updated on 2026-05-05

960

Participants Needed

183

Research Sites

454 weeks

Total Duration

On this page

Sponsors

P

PedAL BCU, LLC

Lead Sponsor

C

Children's Oncology Group

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.

CONDITIONS

Official Title

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

Who Can Participate

Age: 0 - 22Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients must be less than 22 years of age at the time of study enrollment
  • Patient has known or suspected relapsed/refractory acute myeloid leukemia including isolated myeloid sarcoma
  • Patient has known or suspected relapsed/refractory myeloid leukemia of Down syndrome
  • Patient has known or suspected relapsed acute lymphoblastic leukemia meeting specific relapse criteria
  • Patient has known or suspected relapsed/refractory mixed phenotype acute leukemia
  • Patient has known or suspected de novo or relapsed/refractory treatment-related acute myeloid leukemia
  • Patient has known or suspected de novo or relapsed/refractory myelodysplastic syndrome or treatment-related myelodysplastic syndrome
  • Patient has known or suspected de novo or relapsed/refractory juvenile myelomonocytic leukemia
  • All patients and/or their parents or legal guardians must sign a written informed consent
  • All institutional, FDA, and National Cancer Institute requirements for human studies must be met
Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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2
3
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Trial Site Locations

Total: 183 locations

1

Children's Hospital of Alabama

Birmingham, Alabama, United States, 35233

Actively Recruiting

2

USA Health Strada Patient Care Center

Mobile, Alabama, United States, 36604

Actively Recruiting

3

Providence Alaska Medical Center

Anchorage, Alaska, United States, 99508

Actively Recruiting

4

Banner Children's at Desert

Mesa, Arizona, United States, 85202

Actively Recruiting

5

Phoenix Childrens Hospital

Phoenix, Arizona, United States, 85016

Actively Recruiting

6

Banner University Medical Center - Tucson

Tucson, Arizona, United States, 85719

Actively Recruiting

7

Arkansas Children's Hospital

Little Rock, Arkansas, United States, 72202-3591

Actively Recruiting

8

Kaiser Permanente Downey Medical Center

Downey, California, United States, 90242

Actively Recruiting

9

Loma Linda University Medical Center

Loma Linda, California, United States, 92354

Actively Recruiting

10

Miller Children's and Women's Hospital Long Beach

Long Beach, California, United States, 90806

Actively Recruiting

11

Children's Hospital Los Angeles

Los Angeles, California, United States, 90027

Actively Recruiting

12

Valley Children's Hospital

Madera, California, United States, 93636

Actively Recruiting

13

UCSF Benioff Children's Hospital Oakland

Oakland, California, United States, 94609

Actively Recruiting

14

Kaiser Permanente-Oakland

Oakland, California, United States, 94611

Actively Recruiting

15

Children's Hospital of Orange County

Orange, California, United States, 92868

Actively Recruiting

16

Lucile Packard Children's Hospital Stanford University

Palo Alto, California, United States, 94304

Actively Recruiting

17

Rady Children's Hospital - San Diego

San Diego, California, United States, 92123

Not Yet Recruiting

18

UCSF Medical Center-Mission Bay

San Francisco, California, United States, 94158

Actively Recruiting

19

Children's Hospital Colorado

Aurora, Colorado, United States, 80045

Actively Recruiting

20

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

Denver, Colorado, United States, 80218

Actively Recruiting

21

Connecticut Children's Medical Center

Hartford, Connecticut, United States, 06106

Actively Recruiting

22

Yale University

New Haven, Connecticut, United States, 06520

Actively Recruiting

23

Alfred I duPont Hospital for Children

Wilmington, Delaware, United States, 19803

Actively Recruiting

24

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, United States, 20007

Active, Not Recruiting

25

Children's National Medical Center

Washington D.C., District of Columbia, United States, 20010

Actively Recruiting

26

Broward Health Medical Center

Fort Lauderdale, Florida, United States, 33316

Actively Recruiting

27

Golisano Children's Hospital of Southwest Florida

Fort Myers, Florida, United States, 33908

Actively Recruiting

28

UF Health Cancer Institute - Gainesville

Gainesville, Florida, United States, 32610

Actively Recruiting

29

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, Florida, United States, 33021

Actively Recruiting

30

Nemours Children's Clinic-Jacksonville

Jacksonville, Florida, United States, 32207

Actively Recruiting

31

Nicklaus Children's Hospital

Miami, Florida, United States, 33155

Actively Recruiting

32

Arnold Palmer Hospital for Children

Orlando, Florida, United States, 32806

Actively Recruiting

33

Nemours Children's Hospital

Orlando, Florida, United States, 32827

Actively Recruiting

34

Nemours Children's Clinic - Pensacola

Pensacola, Florida, United States, 32504

Actively Recruiting

35

Sacred Heart Hospital

Pensacola, Florida, United States, 32504

Active, Not Recruiting

36

Johns Hopkins All Children's Hospital

St. Petersburg, Florida, United States, 33701

Actively Recruiting

37

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, United States, 33607

Actively Recruiting

38

Saint Mary's Medical Center

West Palm Beach, Florida, United States, 33407

Actively Recruiting

39

Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, Georgia, United States, 30329

Actively Recruiting

40

Memorial Health University Medical Center

Savannah, Georgia, United States, 31404

Actively Recruiting

41

Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, United States, 96826

Actively Recruiting

42

Saint Luke's Cancer Institute - Boise

Boise, Idaho, United States, 83712

Actively Recruiting

43

Lurie Children's Hospital-Chicago

Chicago, Illinois, United States, 60611

Actively Recruiting

44

University of Illinois

Chicago, Illinois, United States, 60612

Actively Recruiting

45

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, United States, 60637

Actively Recruiting

46

Loyola University Medical Center

Maywood, Illinois, United States, 60153

Actively Recruiting

47

Advocate Children's Hospital-Oak Lawn

Oak Lawn, Illinois, United States, 60453

Actively Recruiting

48

Advocate Children's Hospital-Park Ridge

Park Ridge, Illinois, United States, 60068

Actively Recruiting

49

Saint Jude Midwest Affiliate

Peoria, Illinois, United States, 61637

Actively Recruiting

50

Southern Illinois University School of Medicine

Springfield, Illinois, United States, 62702

Actively Recruiting

51

Northwestern Medicine Central DuPage Hospital

Winfield, Illinois, United States, 60190

Actively Recruiting

52

Riley Hospital for Children

Indianapolis, Indiana, United States, 46202

Actively Recruiting

53

Ascension Saint Vincent Indianapolis Hospital

Indianapolis, Indiana, United States, 46260

Actively Recruiting

54

Blank Children's Hospital

Des Moines, Iowa, United States, 50309

Actively Recruiting

55

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, United States, 52242

Actively Recruiting

56

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, United States, 40536

Actively Recruiting

57

Norton Children's Hospital

Louisville, Kentucky, United States, 40202

Actively Recruiting

58

Children's Hospital New Orleans

New Orleans, Louisiana, United States, 70118

Actively Recruiting

59

Ochsner Medical Center Jefferson

New Orleans, Louisiana, United States, 70121

Actively Recruiting

60

Eastern Maine Medical Center

Bangor, Maine, United States, 04401

Actively Recruiting

61

Maine Children's Cancer Program

Scarborough, Maine, United States, 04074

Actively Recruiting

62

Sinai Hospital of Baltimore

Baltimore, Maryland, United States, 21215

Actively Recruiting

63

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, United States, 21287

Actively Recruiting

64

Walter Reed National Military Medical Center

Bethesda, Maryland, United States, 20889-5600

Suspended

65

Dana-Farber Cancer Institute

Boston, Massachusetts, United States, 02215

Actively Recruiting

66

C S Mott Children's Hospital

Ann Arbor, Michigan, United States, 48109

Actively Recruiting

67

Children's Hospital of Michigan

Detroit, Michigan, United States, 48201

Actively Recruiting

68

Michigan State University

East Lansing, Michigan, United States, 48823

Active, Not Recruiting

69

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, Michigan, United States, 49503

Actively Recruiting

70

Bronson Methodist Hospital

Kalamazoo, Michigan, United States, 49007

Actively Recruiting

71

Corewell Health Children's

Royal Oak, Michigan, United States, 48073

Actively Recruiting

72

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, Minnesota, United States, 55404

Actively Recruiting

73

University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, United States, 55455

Actively Recruiting

74

Mayo Clinic in Rochester

Rochester, Minnesota, United States, 55905

Actively Recruiting

75

University of Mississippi Medical Center

Jackson, Mississippi, United States, 39216

Suspended

76

University of Missouri Children's Hospital

Columbia, Missouri, United States, 65212

Actively Recruiting

77

Children's Mercy Hospitals and Clinics

Kansas City, Missouri, United States, 64108

Actively Recruiting

78

Cardinal Glennon Children's Medical Center

St Louis, Missouri, United States, 63104

Actively Recruiting

79

Washington University School of Medicine

St Louis, Missouri, United States, 63110

Actively Recruiting

80

Mercy Hospital Saint Louis

St Louis, Missouri, United States, 63141

Actively Recruiting

81

Children's Hospital and Medical Center of Omaha

Omaha, Nebraska, United States, 68114

Actively Recruiting

82

University of Nebraska Medical Center

Omaha, Nebraska, United States, 68198

Actively Recruiting

83

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, United States, 89135

Actively Recruiting

84

Summerlin Hospital Medical Center

Las Vegas, Nevada, United States, 89144

Actively Recruiting

85

Renown Regional Medical Center

Reno, Nevada, United States, 89502

Actively Recruiting

86

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, United States, 03756

Actively Recruiting

87

Hackensack University Medical Center

Hackensack, New Jersey, United States, 07601

Actively Recruiting

88

Morristown Medical Center

Morristown, New Jersey, United States, 07960

Actively Recruiting

89

Jersey Shore Medical Center

Neptune City, New Jersey, United States, 07753

Actively Recruiting

90

Saint Peter's University Hospital

New Brunswick, New Jersey, United States, 08901

Actively Recruiting

91

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, New Jersey, United States, 08903

Actively Recruiting

92

Saint Joseph's Regional Medical Center

Paterson, New Jersey, United States, 07503

Actively Recruiting

93

University of New Mexico Cancer Center

Albuquerque, New Mexico, United States, 87106

Actively Recruiting

94

Albany Medical Center

Albany, New York, United States, 12208

Actively Recruiting

95

Maimonides Medical Center

Brooklyn, New York, United States, 11219

Actively Recruiting

96

NYU Langone Hospital - Long Island

Mineola, New York, United States, 11501

Actively Recruiting

97

The Steven and Alexandra Cohen Children's Medical Center of New York

New Hyde Park, New York, United States, 11040

Actively Recruiting

98

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, United States, 10016

Actively Recruiting

99

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, United States, 10032

Actively Recruiting

100

Memorial Sloan Kettering Cancer Center

New York, New York, United States, 10065

Actively Recruiting

101

University of Rochester

Rochester, New York, United States, 14642

Active, Not Recruiting

102

Stony Brook University Medical Center

Stony Brook, New York, United States, 11794

Actively Recruiting

103

State University of New York Upstate Medical University

Syracuse, New York, United States, 13210

Actively Recruiting

104

Montefiore Medical Center - Moses Campus

The Bronx, New York, United States, 10467

Suspended

105

New York Medical College

Valhalla, New York, United States, 10595

Actively Recruiting

106

Mission Hospital

Asheville, North Carolina, United States, 28801

Actively Recruiting

107

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, United States, 27599

Actively Recruiting

108

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, United States, 28203

Actively Recruiting

109

Novant Health Presbyterian Medical Center

Charlotte, North Carolina, United States, 28204

Actively Recruiting

110

Duke University Medical Center

Durham, North Carolina, United States, 27710

Actively Recruiting

111

East Carolina University

Greenville, North Carolina, United States, 27834

Actively Recruiting

112

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States, 27157

Actively Recruiting

113

Sanford Broadway Medical Center

Fargo, North Dakota, United States, 58122

Actively Recruiting

114

Children's Hospital Medical Center of Akron

Akron, Ohio, United States, 44308

Actively Recruiting

115

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States, 45229

Actively Recruiting

116

Rainbow Babies and Childrens Hospital

Cleveland, Ohio, United States, 44106

Actively Recruiting

117

Cleveland Clinic Foundation

Cleveland, Ohio, United States, 44195

Active, Not Recruiting

118

Nationwide Children's Hospital

Columbus, Ohio, United States, 43205

Actively Recruiting

119

Dayton Children's Hospital

Dayton, Ohio, United States, 45404

Actively Recruiting

120

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, United States, 43606

Actively Recruiting

121

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States, 73104

Actively Recruiting

122

Legacy Emanuel Children's Hospital

Portland, Oregon, United States, 97227

Actively Recruiting

123

Oregon Health and Science University

Portland, Oregon, United States, 97239

Actively Recruiting

124

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, United States, 18103

Actively Recruiting

125

Geisinger Medical Center

Danville, Pennsylvania, United States, 17822

Actively Recruiting

126

Penn State Children's Hospital

Hershey, Pennsylvania, United States, 17033

Actively Recruiting

127

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

128

Saint Christopher's Hospital for Children

Philadelphia, Pennsylvania, United States, 19134

Actively Recruiting

129

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, United States, 15224

Actively Recruiting

130

Rhode Island Hospital

Providence, Rhode Island, United States, 02903

Actively Recruiting

131

Medical University of South Carolina

Charleston, South Carolina, United States, 29425

Actively Recruiting

132

Prisma Health Richland Hospital

Columbia, South Carolina, United States, 29203

Actively Recruiting

133

BI-LO Charities Children's Cancer Center

Greenville, South Carolina, United States, 29605

Actively Recruiting

134

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, United States, 57117-5134

Actively Recruiting

135

East Tennessee Childrens Hospital

Knoxville, Tennessee, United States, 37916

Actively Recruiting

136

Saint Jude Children's Research Hospital

Memphis, Tennessee, United States, 38105

Actively Recruiting

137

The Children's Hospital at TriStar Centennial

Nashville, Tennessee, United States, 37203

Actively Recruiting

138

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, United States, 37232

Actively Recruiting

139

Dell Children's Medical Center of Central Texas

Austin, Texas, United States, 78723

Actively Recruiting

140

Driscoll Children's Hospital

Corpus Christi, Texas, United States, 78411

Actively Recruiting

141

Medical City Dallas Hospital

Dallas, Texas, United States, 75230

Actively Recruiting

142

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, United States, 75390

Actively Recruiting

143

El Paso Children's Hospital

El Paso, Texas, United States, 79905

Actively Recruiting

144

Cook Children's Medical Center

Fort Worth, Texas, United States, 76104

Actively Recruiting

145

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, United States, 77030

Actively Recruiting

146

M D Anderson Cancer Center

Houston, Texas, United States, 77030

Actively Recruiting

147

Covenant Children's Hospital

Lubbock, Texas, United States, 79410

Actively Recruiting

148

UMC Cancer Center / UMC Health System

Lubbock, Texas, United States, 79415

Actively Recruiting

149

Children's Hospital of San Antonio

San Antonio, Texas, United States, 78207

Actively Recruiting

150

Methodist Children's Hospital of South Texas

San Antonio, Texas, United States, 78229

Actively Recruiting

151

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States, 78229

Actively Recruiting

152

Primary Children's Hospital

Salt Lake City, Utah, United States, 84113

Actively Recruiting

153

University of Virginia Cancer Center

Charlottesville, Virginia, United States, 22908

Actively Recruiting

154

Inova Fairfax Hospital

Falls Church, Virginia, United States, 22042

Actively Recruiting

155

Children's Hospital of The King's Daughters

Norfolk, Virginia, United States, 23507

Actively Recruiting

156

VCU Massey Comprehensive Cancer Center

Richmond, Virginia, United States, 23298

Actively Recruiting

157

Carilion Children's

Roanoke, Virginia, United States, 24014

Actively Recruiting

158

Seattle Children's Hospital

Seattle, Washington, United States, 98105

Actively Recruiting

159

Providence Sacred Heart Medical Center and Children's Hospital

Spokane, Washington, United States, 99204

Actively Recruiting

160

Mary Bridge Children's Hospital and Health Center

Tacoma, Washington, United States, 98405

Actively Recruiting

161

Madigan Army Medical Center

Tacoma, Washington, United States, 98431

Actively Recruiting

162

West Virginia University Healthcare

Morgantown, West Virginia, United States, 26506

Actively Recruiting

163

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, United States, 53792

Actively Recruiting

164

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, United States, 54449

Actively Recruiting

165

The Children's Hospital at Westmead

Westmead, New South Wales, Australia, 2145

Actively Recruiting

166

Queensland Children's Hospital

South Brisbane, Queensland, Australia, 4101

Actively Recruiting

167

Royal Children's Hospital

Parkville, Victoria, Australia, 3052

Actively Recruiting

168

Perth Children's Hospital

Perth, Western Australia, Australia, 6009

Actively Recruiting

169

Alberta Children's Hospital

Calgary, Alberta, Canada, T3B 6A8

Actively Recruiting

170

University of Alberta Hospital

Edmonton, Alberta, Canada, T6G 2B7

Actively Recruiting

171

British Columbia Children's Hospital

Vancouver, British Columbia, Canada, V6H 3V4

Actively Recruiting

172

CancerCare Manitoba

Winnipeg, Manitoba, Canada, R3E 0V9

Actively Recruiting

173

IWK Health Centre

Halifax, Nova Scotia, Canada, B3K 6R8

Actively Recruiting

174

Children's Hospital

London, Ontario, Canada, N6A 5W9

Actively Recruiting

175

Children's Hospital of Eastern Ontario

Ottawa, Ontario, Canada, K1H 8L1

Actively Recruiting

176

Hospital for Sick Children

Toronto, Ontario, Canada, M5G 1X8

Actively Recruiting

177

The Montreal Children's Hospital of the MUHC

Montreal, Quebec, Canada, H3H 1P3

Actively Recruiting

178

Centre Hospitalier Universitaire Sainte-Justine

Montreal, Quebec, Canada, H3T 1C5

Actively Recruiting

179

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Quebec, Canada, J1H 5N4

Actively Recruiting

180

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

Québec, Canada, G1V 4G2

Actively Recruiting

181

Starship Children's Hospital

Grafton, Auckland, New Zealand, 1145

Actively Recruiting

182

Christchurch Hospital

Christchurch, New Zealand, 8011

Actively Recruiting

183

HIMA San Pablo Oncologic Hospital

Caguas, Puerto Rico, 00726

Active, Not Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

SCREENING

Number of Arms

1

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The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study | DecenTrialz