Actively Recruiting
Pediatric Eosinophilic Esophagitis (pedEoE): Effect of Allergen Heat Denaturation on EoE Remission: a Pilot Trial
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2026-05-05
36
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of the study is to study whether the introduction of heated food products (more specifically heated hen's egg and/or cow's milk) in children with EoE would be possible without re-occurrence of the eosinophilic inflammation, while the intake of less heated products might cause disease recidive. Moreover, we would like to study whether the gradual re-introduction of less heated products after the most heated form is tolerated, could lead to tolerance induction in EoE.
CONDITIONS
Official Title
Pediatric Eosinophilic Esophagitis (pedEoE): Effect of Allergen Heat Denaturation on EoE Remission: a Pilot Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 12 months and older diagnosed with pediatric eosinophilic esophagitis (pedEoE)
- Diagnosed since January 1, 2014, with elimination of hen's egg, cow's milk, or both
- In complete remission after latest biopsy no longer than 12 months ago (or new biopsy if older)
- Stable on proton pump inhibitor (PPI) and/or local budesonide treatment for at least 3 months if applicable
- Able to provide informed consent (parents) and assent (children when old enough)
You will not qualify if you...
- Children younger than 12 months
- Children with active pediatric eosinophilic esophagitis
- Children who refuse to follow the study protocol
- Children with IgE-mediated hen's egg and/or cow's milk allergy with antibody levels predicting active baked egg or milk allergy (unless titers decrease during study)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UZ Leuven Gasthuisberg
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
Research Team
D
Dominique Bullens, Prof. Dr.
CONTACT
M
Marleen Jannis
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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