Study of Angiotensin-1-7 and Related Factors in Children Ages 7 to 18 with New Hypertension or Normal Blood Pressure Examining Heart and Kidney Effects and Treatment Responses

What this Trial Is About

This research aims to understand how specific components of the renin-angiotensin-aldosterone system, uric acid, and klotho contribute to high blood pressure and related damage in children and adolescents aged 7 to 18 years. It compares children newly diagnosed with primary hypertension to healthy controls, investigating how these biological factors affect the heart, kidneys, blood vessels, and brain over time. The study focuses on the variability in disease traits and treatment responses using detailed biological and clinical measurements. Participants are divided into two groups children with newly diagnosed primary hypertension and healthy children with normal blood pressure. Blood and urine samples are collected to analyze levels of various substances such as Ang-1-7, ACE2, and uric acid. Blood pressure, heart function and structure, kidney function, autonomic nervous system function, and vascular function are measured at the start, after one year for both groups, and after two years for the hypertension group, allowing researchers to observe changes over time and responses to treatment. Throughout the study, participants undergo multiple assessments including blood and urine tests, blood pressure monitoring, echocardiograms, and measurements of autonomic and vascular function. These evaluations occur at baseline, one year, and two years to track health changes and treatment effects. The study also monitors changes in biomarkers and organ function to better understand hypertensions impact and guide future patient care. Participants and their caregivers are expected to commit to completing all assessments during the study period.

Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)