Perioperative paediatric patient blood management: a narrative review.
Susan M Goobie, David Faraoni
https://pubmed.ncbi.nlm.nih.gov/39455307/Actively Recruiting
Led by University of British Columbia · Updated on 2026-05-14
180
Participants Needed
1
Research Sites
N/A
Total Duration
This research aims to improve surgical outcomes for children undergoing varus-derotation osteotomy VDRO or pelvic osteotomy, surgeries to prevent or treat hip displacement. Many of these children have cerebral palsy or other neuromotor disorders and face a higher risk of malnutrition and iron deficiency anemia, which can increase the need for blood transfusions during surgery. The study focuses on developing a comprehensive preoperative nutritional program, including iron supplementation when needed, to reduce these risks and improve recovery. Participants aged 0 to 18 scheduled for VDRO or pelvic osteotomy will be evaluated by a dietitian and have lab tests to check for iron deficiency. Those with low iron will receive iron supplements along with dietary education and other nutrition management, while those with adequate iron will receive nutrition support without iron supplements. The study also includes a historical comparison group who had surgery without these interventions. Iron supplementation dosing and other nutritional support like vitamin supplements, tube feed optimization, and dietary education are tailored to each patients needs. During the study, participants will be monitored through lab tests, nutrition assessments, and surveys to track adherence and family satisfaction. Researchers will measure outcomes such as the rate of blood transfusions during hospital stay, resolution of anemia, iron levels, surgical site infections, pressure wounds, and length of hospital stay. The study spans a two-year period, with follow-up up to 12 months after surgery, to assess the impact of the nutritional program on surgical recovery and overall health.
CONDITIONS
Pediatric Outcomes and Recovery With Peri-Operative Iron Supplement Evaluation
S
Steffanie Fisher, MSc
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University of British Columbia
Lead Sponsor
BC Children's Hospital Research Institute
Collaborating Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - Up to surgery date (variable depending on individual scheduling)
Participants undergo comprehensive nutrition assessment and management including evaluation for iron deficiency anemia. Those with iron deficiency receive iron supplementation and education on enhancing iron intake, while all participants receive nutrition management tailored by a dietitian.
1 to 2 visits depending on nutritional needs and iron supplementation requirements
Duration - From surgery day to hospital discharge
Participants undergo varus-derotational osteotomy (VDRO) or pelvic osteotomy surgery and receive perioperative care including monitoring for blood transfusion and surgical complications.
Hospital stay with continuous monitoring
Duration - Up to 12 months post-surgery
Participants are monitored for resolution of anemia, iron levels, surgical site infections, pressure wounds, and recovery progress up to 12 months after surgery. Follow-up includes surveys assessing compliance, tolerance, and family satisfaction.
Periodic visits and online surveys during 12 months follow-up
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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https://pubmed.ncbi.nlm.nih.gov/8314827/University of British Columbia
Lead Sponsor
BC Children's Hospital Research Institute
Collaborating Sponsor