Actively Recruiting
Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
Led by Children's Hospital Los Angeles · Updated on 2025-02-07
60
Participants Needed
1
Research Sites
133 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced. The primary and secondary aims of the study are as follows: Identify the difference between the optimal PEEP recommended by EIT metrics and the current guideline recommended approach to identifying optimal PEEP in PARDS. There will be a statistically significant difference in the recommended optimal PEEP identified using the EIT PEEP titration tool and that of the PEEP/FiO2 grid recommendations. Determine the difference in physiologic metrics between EIT optimal PEEP and the PEEP/FiO2 recommended PEEP. Participants will undergoing EIT monitoring while being subjected to PEEP titration protocol.
CONDITIONS
Official Title
Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is less than 18 years of age
- Patient is on invasive mechanical ventilation
- Patient is not spontaneously breathing
- Patient meets Pediatric Acute Respiratory Distress Syndrome (PARDS) criteria
You will not qualify if you...
- Contraindication to the use of electrical impedance tomography (EIT)
- Hemodynamic instability
- Contraindications to hypercapnia
- Presence of uncuffed endotracheal or tracheostomy tubes
- Diagnosis of pneumothorax or bronchopleural fistula
- Use of non-conventional ventilation
- Patient is on extracorporeal membrane oxygenation (ECMO) support
- Less than 1 week post-operative from cardiac surgery
- Cardiac diagnoses including Glenn or Fontan physiology or significant right to left shunt
- Corrected gestational age less than 37 weeks
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027
Actively Recruiting
Research Team
H
Hayden Leeds, MD
CONTACT
A
Anoopindar Bhalla, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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