Actively Recruiting
PEEP in Patients With Acute Respiratory Failure
Led by Jesus Villar · Updated on 2025-04-20
15
Participants Needed
3
Research Sites
237 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support. In 1975, several investigators published the effects of PEEP in 15 mechanically ventilated patients with acute respiratory failure (ARF) supported by mechanical ventilation. FiO2 ranged between 21% to 75% and the tidal volume between 13 to 15 mL/kg. PEEP was increased in 3 cmH2O steps until cardiac output fell. The aim was to identify the "optimum" PEEP level. "Best" PEEP was associated simultaneously with the best static compliance of the respiratory system, the greatest oxygen transport, and the lowest dead space fraction. That study established the basis for the use of PEEP in patients with ARF worldwide. Although currently patients with ARF are ventilated with much lower tidal volumes, that study has never been validated. It is unknow whether their findings are currently valid, generalizable, and reproducible.
CONDITIONS
Official Title
PEEP in Patients With Acute Respiratory Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Intubated patients requiring mechanical ventilation for more than 24 hours
- Age over 18 years
- Acute hypoxemic respiratory failure defined as PaO2/FiO2 less than 300 with FiO2 of 0.3 or higher and PEEP of 5 cmH2O or more
- Respiratory failure caused by lung injuries such as atelectasis, lung contusion, aspiration, or lung infection
You will not qualify if you...
- Respiratory failure from non-pulmonary causes
- Contraindications to high PEEP such as severe head trauma or severe chest trauma
- Patients unable to maintain a supine position
- Uncorrected low blood volume (hypovolemia)
- Hemodynamic instability
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Hospital Universitario Dr. Negrin
Las Palmas de Gran Canaria, Las Palmas, Spain, 35019
Actively Recruiting
2
Hospital Clinic
Barcelona, Spain
Not Yet Recruiting
3
Hospital Universitario La Princesa
Madrid, Spain
Not Yet Recruiting
Research Team
J
Jesús Villar, MD
CONTACT
A
Angel Becerra, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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