Actively Recruiting
PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest
Led by Muehlenkreiskliniken, MKK · Updated on 2025-08-06
600
Participants Needed
3
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.
CONDITIONS
Official Title
PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years
- Non-traumatic out-of-hospital cardiac arrest
- Mechanical ventilation via airway device
You will not qualify if you...
- Patients younger than 18 years
- Traumatic cause of out-of-hospital cardiac arrest
- No cardiac arrest or resuscitation withheld (e.g., Do-Not-Resuscitate orders)
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Emergency Medical Services
Gütersloh, North Rhine-Westphalia, Germany, 33324
Actively Recruiting
2
JWK Minden
Minden, North Rhine-Westphalia, Germany, 32429
Actively Recruiting
3
Emergency Medical Services
Osnabrück, Germany
Actively Recruiting
Research Team
G
Gerrit Jansen, PD Dr. med.
CONTACT
J
Jochen Hinkelbein, Prof. Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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