Comparing Two Types of Regional Anesthesia for Pain Relief After Hip Replacement Surgery in Older Adults
A Randomized Study of PENG Block Versus Lumbar and Sacral ESP Blocks in Total Hip Arthroplasty
Led by Poznan University of Medical Sciences · Updated on 2026-05-07
90
Participants Needed
1
Research Sites
8 weeks
Total Duration
AI-Summary
What this Trial Is About
This research aims to compare two types of regional anesthesia to see which better controls pain and supports recovery after total hip replacement surgery in adults aged 65 and older. It focuses on whether the Pericapsular Nerve Group PENG block reduces opioid use more effectively than the combination of Lumbar and Sacral Erector Spinae Plane Blocks L-ESPB S-ESPB. The study also evaluates which method offers better pain relief, preserves muscle strength, and helps patients walk sooner after surgery.
Participants will be randomly assigned to one of two groups receiving ultrasound-guided nerve blocks along with standard spinal anesthesia and postoperative pain management. One group receives the PENG block plus a lateral femoral cutaneous nerve LFCN block with sham injections at lumbar and sacral sites. The other group receives lumbar and sacral ESP blocks with sham PENG and LFCN injections. All patients will have spinal anesthesia with ropivacaine during surgery.
During the study, participants will be monitored for total opioid use over the first 48 hours after surgery, pain scores at multiple time points up to 48 hours, time to first walking, quadriceps muscle strength, satisfaction, and side effects. These measures will help determine which anesthesia approach provides better pain control and faster functional recovery following hip replacement. The study starts in September 2025 and continues until November 2026.
CONDITIONS
Brief Title
PENG vs L-ESPB With S-ESPB for Analgesia in Total Hip Arthroplasty
Research Team
M
Malgorzata Reysner, M.D. Ph.D.
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Scheduled for elective unilateral total hip arthroplasty via posterior or lateral approach
Provided informed consent
You will not qualify if you...
Allergy to study drugs such as ropivacaine or dexamethasone
Chronic opioid use greater than 30 MME per day
Bleeding disorders or infection at injection sites
Body mass index over 40 kg/m²
Existing motor weakness or neuropathy in the affected leg
Cognitive impairment preventing informed consent
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Surgery day plus 48 hours postoperatively
Participants receive spinal anesthesia and are randomly assigned to receive either a pericapsular nerve group (PENG) block with lateral femoral cutaneous nerve (LFCN) block, lumbar erector spinae plane block (L-ESPB) with sacral ESPB (S-ESPB), or a placebo procedure, all during total hip arthroplasty surgery.
1 surgical procedure and postoperative assessments over 2 days
Follow-up
Duration - 48 hours after surgery
Participants are monitored for pain, opioid consumption, muscle strength, and time to ambulation up to 48 hours after surgery to assess recovery and analgesic effectiveness.
Multiple assessments within 48 hours post-surgery
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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Published Research Related To This Trial
Comparison of pericapsular nerve group block combined with a lateral femoral cutaneous nerve (LFCN) block versus lumbar and sacral erector spinae plane blocks for analgesia after total hip arthroplasty: study protocol for a randomized, controlled trial with blinded outcome assessment.