Actively Recruiting
Penile Skin Versus Buccal Mucosal Graft in Augmentation Urethroplasty for Long Anterior Urethral Stricture: A Prospective Randomized Study
Led by Tanta University · Updated on 2025-07-20
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The trial investigates two surgical methods for treating long segment bulbar urethral stricture, a condition involving narrowing of the urethra. Researchers aim to compare the outcomes of dorsal onlay buccal mucosal graft (BMG) versus penile skin graft (PSG) urethroplasty, both established techniques used to manage this challenging condition. The study is a prospective randomized evaluation sponsored by Tanta University to assess surgical success and related outcomes. Participants will undergo one of two types of dorsal onlay augmentation urethroplasty under spinal or general anesthesia. One group receives a buccal mucosal graft harvested from the inner cheek, which is sutured dorsally over the strictured urethral segment after removing fibrotic tissue. The other group receives a penile skin graft taken from the ventral surface of the penis, also applied dorsally after excision of the fibrotic area. Both procedures focus on reconstructing the urethra to relieve the stricture. During the study, participants will be monitored for surgical success at 9 months after surgery, which is the primary outcome. Secondary measures include symptom assessment using the International Prostate Symptom Score (IPSS), the length of the urethral stricture measured during surgery, and any postoperative complications up to 9 months. The study involves random assignment to either surgical technique and does not use blinding.
CONDITIONS
Brief Title
Penile Skin Versus Buccal Mucosal Graft in Augmentation Urethroplasty for Long Anterior Urethral Stricture
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male patients aged 18 years or older
- Diagnosis of long segment anterior urethral stricture longer than 1 cm with spongiofibrosis
- History of previous failed urethral dilatation or direct vision internal urethrotomy (DVIU)
You will not qualify if you...
- Presence of lichen sclerosus
- History of hypospadias repair
- Recurrent urethral stricture after failed previous urethroplasty
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day and immediate recovery period
Participants undergo dorsal onlay augmentation urethroplasty using either a buccal mucosal graft harvested from the inner cheek or a penile skin graft harvested from the ventral surface of the penis. The surgery is performed under spinal or general anesthesia, followed by immediate post-operative care.
1 surgical visit (in-person)
Duration - Up to 9 months postoperatively
Participants are monitored for surgical success, symptom improvement, and any complications following the urethroplasty.
Approximately 3 to 4 visits over 9 months (in-person)
Trial Site Locations
Total: 1 location
1
Tanta University
Tanta, El-Gharbia Governorate, Egypt, Egypt, 31527
Actively Recruiting
Research Team
M
Mohamed I Elmaadawy, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here