Actively Recruiting
PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest
Led by University of California, San Francisco · Updated on 2025-07-08
52
Participants Needed
1
Research Sites
126 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Brain injury is the main cause of death and disability for patients surviving cardiac arrest resuscitation and seizures are diagnosed in up to a third of these patients. The investigators are proposing a pilot randomized placebo-controlled clinical trial to evaluate the safety and feasibility of perampanel use for post-cardiac arrest status epilepticus (PCARSE) prevention after cardiac arrest.
CONDITIONS
Official Title
PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Non-traumatic, out-of-hospital cardiac arrest
- Comatose on admission, defined as not following commands
- Return of spontaneous circulation within less than 45 minutes from the time of cardiac arrest (911 or EMS witnessed arrest)
- Admission to the intensive care unit at Zuckerberg San Francisco General Hospital
You will not qualify if you...
- Acute cerebral hemorrhage or infarction
- Pregnancy
- Prisoner status
- Severe kidney impairment with creatinine clearance below 30 ml/min
- Severe liver impairment with liver function tests five times above the upper limit of normal
- Electrographic or electroclinical seizures diagnosed using American Clinical Neurophysiology criteria confirmed by an epileptologist after cardiac arrest
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zuckerberg San Francisco General Hospital
San Francisco, California, United States, 94110
Actively Recruiting
Research Team
E
Edilberto Amorim, MD
CONTACT
K
Kevin Bao, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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